Skip to main content

Main menu

  • Home
  • Content
    • Current
    • Ahead of print
    • Past Issues
    • JNM Supplement
    • SNMMI Annual Meeting Abstracts
    • Continuing Education
    • JNM Podcasts
  • Subscriptions
    • Subscribers
    • Institutional and Non-member
    • Rates
    • Journal Claims
    • Corporate & Special Sales
  • Authors
    • Submit to JNM
    • Information for Authors
    • Assignment of Copyright
    • AQARA requirements
  • Info
    • Reviewers
    • Permissions
    • Advertisers
  • About
    • About Us
    • Editorial Board
    • Contact Information
  • More
    • Alerts
    • Feedback
    • Help
    • SNMMI Journals
  • SNMMI
    • JNM
    • JNMT
    • SNMMI Journals
    • SNMMI

User menu

  • Subscribe
  • My alerts
  • Log in
  • My Cart

Search

  • Advanced search
Journal of Nuclear Medicine
  • SNMMI
    • JNM
    • JNMT
    • SNMMI Journals
    • SNMMI
  • Subscribe
  • My alerts
  • Log in
  • My Cart
Journal of Nuclear Medicine

Advanced Search

  • Home
  • Content
    • Current
    • Ahead of print
    • Past Issues
    • JNM Supplement
    • SNMMI Annual Meeting Abstracts
    • Continuing Education
    • JNM Podcasts
  • Subscriptions
    • Subscribers
    • Institutional and Non-member
    • Rates
    • Journal Claims
    • Corporate & Special Sales
  • Authors
    • Submit to JNM
    • Information for Authors
    • Assignment of Copyright
    • AQARA requirements
  • Info
    • Reviewers
    • Permissions
    • Advertisers
  • About
    • About Us
    • Editorial Board
    • Contact Information
  • More
    • Alerts
    • Feedback
    • Help
    • SNMMI Journals
  • View or Listen to JNM Podcast
  • Visit JNM on Facebook
  • Join JNM on LinkedIn
  • Follow JNM on Twitter
  • Subscribe to our RSS feeds
Meeting ReportGeneral Clinical Specialties Track

Ectopic Gastric Mucosa with Intense Iodine Uptake in the Esophagus Mimicking Thoracic Metastasis - A Case Report

Adelina Sanches, Lais Sousa, Tiago Costa and Carolina Cruz
Journal of Nuclear Medicine May 2016, 57 (supplement 2) 1708;
Adelina Sanches
2Nuclear Medicine Grupo Delfin/ Santa Casa de Misericordia Bahia Salvador Brazil
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Lais Sousa
3Nuclear Medicine Universidade de São Paulo Salvador Brazil
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Tiago Costa
1Nuclear Medicine Grupo Delfin Salvador Brazil
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Carolina Cruz
1Nuclear Medicine Grupo Delfin Salvador Brazil
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Info & Metrics
Loading

Abstract

1708

Objectives We report a case of Ectopic Gastric Mucosa with Intense Iodine Uptake in the Esophagus Mimicking Thoracic Metastasis

Methods Case Report

Results Thyroid cancer is the most common endocrine cancer (1.0-1.5% of all new cancers in the USA). Iodine-131 (I-131) whole-body scan (WBS) plays an important role in the management of patients with differentiated thyroid carcinoma (DTC), to detect normal thyroid remnants and recurrent or metastatic disease. A focus of I-131 accumulation outside the thyroid bed and out of the areas of physiological uptake are strongly suggestive of metastasis. However, many false-positive findings have been reported in the literature. MBC, 46 year old male, underwent total thyroidectomy for DTC which revealed papillary carcinoma in the right lobe, with 1,8 cm and extensive invasion of the capsule of the thyroid gland, but with only focal extra glandular involvement. One out of 5 lymphnodes removed was metastatic. He performed staging with lab, ultrasound and a WBS with I-131. The thyroglobulin (Tg) level was 2.2 ng/ ml, negative antibodies, TSH: 6.8 (not yet on complete suppression), negative ultrasound, but the WBS shown an intense uptake on the midthorax. A therapeutic dose of 150 mCi was administered under recombinant human TSH, with peak Tg of 13.3, which fell to 0 post iodine. On the WBS post treatment besides the uptake in the thyroid bed, the same image in midthorax was seen. At this time we performed a SPECT with CT fusion imaging, which showed that the area was located in the esophagus. An endoscopy found out the presence of an atypical tissue that was biopsied and revealed ectopic gastric mucosa (EGM). EGM of the esophagus is uncommon with endoscopic studies reporting a prevalence ranging from 1-18%. The causes of iodine uptake in EGM are functional NIS expression in gastrointestinal tract and retention of I-131 in mucosal secretions, associated with or without structural changes. In this reported case, we show a patient with low Tg with a persistent focal iodine uptake in midthorax. According to current practice, the observation of I-131 uptake suggestive of metastasis of a DTC must be evaluated together with a clinical scenario, which involves high Tg serum levels, an anatomic altered imaging and a history that would favor metastatic cancer. An isolated I-131 uptake is unlikely to be a metastasis, but rather a false-positive finding as shown in the present case. Using advanced hybrid imaging in nuclear medicine might help to solve the issue.

Conclusions We report a case that shows that performing hybrid imaging and evaluating the clinical context can avoid false-positive findings in the iodine whole body imaging.

Previous
Back to top

In this issue

Journal of Nuclear Medicine
Vol. 57, Issue supplement 2
May 1, 2016
  • Table of Contents
  • Index by author
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for your interest in spreading the word on Journal of Nuclear Medicine.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Ectopic Gastric Mucosa with Intense Iodine Uptake in the Esophagus Mimicking Thoracic Metastasis - A Case Report
(Your Name) has sent you a message from Journal of Nuclear Medicine
(Your Name) thought you would like to see the Journal of Nuclear Medicine web site.
Citation Tools
Ectopic Gastric Mucosa with Intense Iodine Uptake in the Esophagus Mimicking Thoracic Metastasis - A Case Report
Adelina Sanches, Lais Sousa, Tiago Costa, Carolina Cruz
Journal of Nuclear Medicine May 2016, 57 (supplement 2) 1708;

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Share
Ectopic Gastric Mucosa with Intense Iodine Uptake in the Esophagus Mimicking Thoracic Metastasis - A Case Report
Adelina Sanches, Lais Sousa, Tiago Costa, Carolina Cruz
Journal of Nuclear Medicine May 2016, 57 (supplement 2) 1708;
Twitter logo Facebook logo LinkedIn logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One
Bookmark this article

Jump to section

  • Article
  • Info & Metrics

Related Articles

  • No related articles found.
  • Google Scholar

Cited By...

  • No citing articles found.
  • Google Scholar

More in this TOC Section

General Clinical Specialties Track

  • Quantitative Evaluation of Parathyroid Adenoma and Hyperplasia in Reference to Thyroid using Tc-99m MIBI SPECT/CT
  • A primitive study for clinical application of 18F-AlF-NOTA-octreotide PET/CT in combination with 18F-FDG PET/CT for imaging neuroendocrine neoplasms
  • Role of 18F-FDG PET/CT in detection of disease burden and response assessment in patients with myeloid sarcoma
Show more General Clinical Specialties Track

MTA II: Endocrinology/Neuroendocrine Posters

  • A PET study of burn-induced tissue-specific insulin resistance
  • Impaired Insulin Sensitive Glucose Utilization at Brown Adipose Tissue in Obese Diabetic Rats
  • The Efficacy of Retinoic Acid in Patients with Radioiodine-Refractory Thyroid Cancer: A Meta-analysis
Show more MTA II: Endocrinology/Neuroendocrine Posters

Similar Articles

SNMMI

© 2025 SNMMI

Powered by HighWire