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Research ArticleSupplement

Bone-Targeted Imaging and Radionuclide Therapy in Prostate Cancer

Andrei H. Iagaru, Erik Mittra, Patrick M. Colletti and Hossein Jadvar
Journal of Nuclear Medicine October 2016, 57 (Supplement 3) 19S-24S; DOI: https://doi.org/10.2967/jnumed.115.170746
Andrei H. Iagaru
1Division of Nuclear Medicine and Molecular Imaging, Department of Radiology, Stanford University, Stanford, California; and
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Erik Mittra
1Division of Nuclear Medicine and Molecular Imaging, Department of Radiology, Stanford University, Stanford, California; and
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Patrick M. Colletti
2Division of Nuclear Medicine, Department of Radiology, Keck School of Medicine, University of Southern California, Los Angeles, California
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Hossein Jadvar
2Division of Nuclear Medicine, Department of Radiology, Keck School of Medicine, University of Southern California, Los Angeles, California
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  • FIGURE 1.
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    FIGURE 1.

    18F-NaF PET/CT maximum-intensity-projection images illustrating appearance of anterior osteophyte (A), solitary metastasis (B), and multiple metastases (C) in 3 different PC patients.

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    FIGURE 2.

    73-y-old man with PC. (A and B) 99mTc-MDP bone scan was negative (A), whereas 18F-NaF PET/CT revealed single L4 metastasis (B). (C and D) Axial PET (C) and CT (D) revealed focal uptake in small sclerotic lesion (arrowhead).

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    FIGURE 3.

    72-y-old man who had PC and was referred for 153Sm-EDTMP treatment of painful bone metastases. 99mTc-MDP bone scan (A) and 153Sm-EDTMP (B) revealed extensive metastases.

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    FIGURE 4.

    Biodistribution of 223RaCl2. (Adapted with permission of (47).)

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    TABLE 1

    Bone-Targeted Radiopharmaceuticals

    RadiopharmaceuticalPhysical half-life (d)Particle typeUsual administered activityTypical response time (d)Typical response durationRetreatment interval
    89SrCl2 (Metastron; GE Healthcare Ltd.)50.5β148 MBq14–2812–26 wk>3 mo
    153Sm-EDTMP (Quadramet; IBA-Molecular)1.9β37 MBq/kg2–78 wk>2 mo
    223RaCl2 (Xofigo; Bayer Healthcare)11.4α50 kBq/kg × 6 every 4 wk<10UnknownUnknown
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Journal of Nuclear Medicine: 57 (Supplement 3)
Journal of Nuclear Medicine
Vol. 57, Issue Supplement 3
October 1, 2016
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Bone-Targeted Imaging and Radionuclide Therapy in Prostate Cancer
Andrei H. Iagaru, Erik Mittra, Patrick M. Colletti, Hossein Jadvar
Journal of Nuclear Medicine Oct 2016, 57 (Supplement 3) 19S-24S; DOI: 10.2967/jnumed.115.170746

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Bone-Targeted Imaging and Radionuclide Therapy in Prostate Cancer
Andrei H. Iagaru, Erik Mittra, Patrick M. Colletti, Hossein Jadvar
Journal of Nuclear Medicine Oct 2016, 57 (Supplement 3) 19S-24S; DOI: 10.2967/jnumed.115.170746
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  • Article
    • Abstract
    • 18F-NAF PET IN PC
    • 18F-NAF PET/CT VS. 99MTC-MDP BONE SCINTIGRAPHY
    • TARGETED RADIONUCLIDE THERAPY FOR BONE METASTASES
    • 89SRCL2 AND 153SM-ETHYLENEDIAMINETETRAMETHYLENE PHOSPHONATE (153SM-EDTMP)
    • 223RACL2
    • CONCLUSION
    • DISCLOSURE
    • REFERENCES
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More in this TOC Section

  • Advancing Global Nuclear Medicine: The Role and Future Contributions of China
  • Advantages and Challenges of Total-Body PET/CT at a Tertiary Cancer Center: Insights from Sun Yat-sen University Cancer Center
  • Pathway to Approval of Innovative Radiopharmaceuticals in China
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Keywords

  • PET/CT
  • PET
  • prostate
  • cancer
  • Bone
  • radium
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