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Research ArticleClinical Investigations

Noninvasive Quantification of Myocardial 11C-Meta-Hydroxyephedrine Kinetics

Hendrik J. Harms, Marc C. Huisman, Mischa T. Rijnierse, Henri Greuter, Yu-Lung Hsieh, Stefan de Haan, Robert C. Schuit, Paul Knaapen, Mark Lubberink and Adriaan A. Lammertsma
Journal of Nuclear Medicine September 2016, 57 (9) 1376-1381; DOI: https://doi.org/10.2967/jnumed.115.167437
Hendrik J. Harms
1Department of Radiology and Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherlands
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Marc C. Huisman
1Department of Radiology and Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherlands
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Mischa T. Rijnierse
2Department of Cardiology, VU University Medical Center, Amsterdam, The Netherlands
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Henri Greuter
1Department of Radiology and Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherlands
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Yu-Lung Hsieh
3Philips Healthcare, Cleveland, Ohio; and
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Stefan de Haan
2Department of Cardiology, VU University Medical Center, Amsterdam, The Netherlands
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Robert C. Schuit
1Department of Radiology and Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherlands
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Paul Knaapen
2Department of Cardiology, VU University Medical Center, Amsterdam, The Netherlands
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Mark Lubberink
1Department of Radiology and Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherlands
4Nuclear Medicine and PET, Uppsala University, Akademiska sjukhuset, Uppsala, Sweden
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Adriaan A. Lammertsma
1Department of Radiology and Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherlands
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  • FIGURE 1.
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    FIGURE 1.

    Population-averaged IDIF (red lines: 3DR; blue lines: TF) and BSIF (green lines) for peaks (A) and tails (B) of the curves. Dotted lines indicate mean ± SD.

  • FIGURE 2.
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    FIGURE 2.

    Correlation (A) and Bland–Altman (B) plots for K1 obtained using BSIF and both IDIF3DR (red) and IDIFTF (blue). (A) Solid lines represent linear fits, and dashed lines indicate lines of identity. (B) Solid lines represent mean difference, and dashed lines indicate 95% confidence intervals.

  • FIGURE 3.
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    FIGURE 3.

    Correlation (A) and Bland–Altman (B) plots for VT obtained using BSIF and both IDIF3DR (red) and IDIFTF (blue). (A) Solid lines represent linear fits, and dashed line is line of identity. (B) Solid lines represent mean difference, and dashed lines indicate 95% confidence intervals.

  • FIGURE 4.
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    FIGURE 4.

    (A) Plasma–to–whole-blood ratio (PBR, red) and parent fraction (PF, blue) for arterial (PWBart and PFart, continuous lines) and venous (PWBven and PFven, dashed lines) blood samples as function of time. (B) Ratio of venous and arterial PBRs (red) and PFs (blue) as function of time.

  • FIGURE 5.
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    FIGURE 5.

    Correction factors for plasma–to–whole-blood ratio (PWR, red dots) and parent fraction (PF, blue dots) derived from arterial (horizontal axis) and venous (vertical axis) blood data. Lines indicate fits derived using a second-order polynomial, of which inverse was used to transform venous data into arterial data (Eqs. 2 and 3).

  • FIGURE 6.
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    FIGURE 6.

    Correlation plots of K1 (A) and VT (B), calculated using venous (red) and transformed venous (blue) data, with corresponding parameters obtained using arterial data. Solid lines represent linear fits, and black dashed lines depict lines of identity.

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Journal of Nuclear Medicine: 57 (9)
Journal of Nuclear Medicine
Vol. 57, Issue 9
September 1, 2016
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Noninvasive Quantification of Myocardial 11C-Meta-Hydroxyephedrine Kinetics
Hendrik J. Harms, Marc C. Huisman, Mischa T. Rijnierse, Henri Greuter, Yu-Lung Hsieh, Stefan de Haan, Robert C. Schuit, Paul Knaapen, Mark Lubberink, Adriaan A. Lammertsma
Journal of Nuclear Medicine Sep 2016, 57 (9) 1376-1381; DOI: 10.2967/jnumed.115.167437

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Noninvasive Quantification of Myocardial 11C-Meta-Hydroxyephedrine Kinetics
Hendrik J. Harms, Marc C. Huisman, Mischa T. Rijnierse, Henri Greuter, Yu-Lung Hsieh, Stefan de Haan, Robert C. Schuit, Paul Knaapen, Mark Lubberink, Adriaan A. Lammertsma
Journal of Nuclear Medicine Sep 2016, 57 (9) 1376-1381; DOI: 10.2967/jnumed.115.167437
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