RT Journal Article
SR Electronic
T1 Noninvasive Quantification of Myocardial <sup>11</sup>C-<em>Meta</em>-Hydroxyephedrine Kinetics
JF Journal of Nuclear Medicine
JO J Nucl Med
FD Society of Nuclear Medicine
SP 1376
OP 1381
DO 10.2967/jnumed.115.167437
VO 57
IS 9
A1 Harms, Hendrik J.
A1 Huisman, Marc C.
A1 Rijnierse, Mischa T.
A1 Greuter, Henri
A1 Hsieh, Yu-Lung
A1 de Haan, Stefan
A1 Schuit, Robert C.
A1 Knaapen, Paul
A1 Lubberink, Mark
A1 Lammertsma, Adriaan A.
YR 2016
UL http://jnm.snmjournals.org/content/57/9/1376.abstract
AB 11C-meta-hydroxyephedrine (11C-HED) kinetics in the myocardium can be quantified using a single-tissue-compartment model together with a metabolite-corrected arterial blood sampler input function (BSIF). The need for arterial blood sampling, however, limits clinical applicability. The purpose of this study was to investigate the feasibility of replacing arterial sampling with imaging-derived input function (IDIF) and venous blood samples. Methods: Twenty patients underwent 60-min dynamic 11C-HED PET/CT scans with online arterial blood sampling. Thirteen of these patients also underwent venous blood sampling. Data were reconstructed using both 3-dimensional row-action maximum-likelihood algorithm (3DR) and a time-of-flight (TF) list-mode reconstruction algorithm. For each reconstruction, IDIF results were compared with BSIF results. In addition, IDIF results obtained with venous blood samples and with a transformed venous-to-arterial metabolite correction were compared with results obtained with arterial metabolite corrections. Results: Correlations between IDIF- and BSIF-derived K1 and VT were high (r2 &gt; =0.89 for 3DR and TF). Slopes of the linear fits were significantly different from 1 for K1, for both 3DR (slope = 0.94) and TF (slope = 1.06). For VT, the slope of the linear fit was different from 1 for TF (slope = 0.93) but not for 3DR (slope = 0.98). Use of venous blood data introduced a large bias in VT (r2 = 0.96, slope = 0.84) and a small bias in K1 (r2 = 0.99, slope = 0.98). Use of a second-order polynomial venous-to-arterial transformation was robust and greatly reduced bias in VT (r2 = 0.97, slope = 0.99) with no effect on K1. Conclusion: IDIF yielded precise results for both 3DR and TF. Venous blood samples can be used for absolute quantification of 11C-HED studies, provided a venous-to-arterial transformation is applied. A venous-to-arterial transformation enables noninvasive, absolute quantification of 11C-HED studies.