Article Figures & Data
Figures
- FIGURE 1.
Effects of treatment with MPTP on postsynaptic dopamine parameters and MC-I activity in striatum of monkey brain. Typical PET images of normal monkey (top) and MPTP-treated monkey (bottom) are presented. PET scans for DAT (A; 11C-β-CFT) and dopamine synthesis (β-11C-L-DOPA [B], 18F-FDOPA [C], and 11C-6MemTyr [D]) were acquired for 91 min without arterial blood sampling. PET scans for MC-I (E; 18F-BCPP-EF) were obtained for 91 min with sequential arterial blood sampling.
- FIGURE 2.
Relationships between Vt of 18F-BCPP-EF and BPND of 11C-β-CFT (○,●) (A) and between MTGA Ki values of 18F-FDOPA (□,▪▪▪), β-11C-L-DOPA (△,), and 11C-6MemTyr (○,●) (B) in striatum of living monkey brain. These correlation analyses involved normal (open symbols) and PD animals (closed symbols). Correlation analyses against MC-I activity were conducted using imaging results from 1 of 2 striata from single animal (8 monkeys total; 4 controls and 4 MPTP-treated). DA = dopamine synthesis.
- FIGURE 3.
Relationships between MPTP-induced percentage reduction of 11C-6MemTyr (●), 11C-L-DOPA (▪▪▪), 18F-FDOPA (▪▪▪), or 11C-β-CFT (○) against percentage reduction of 18F-BCPP-EF in striatum of living monkey brain. Correlation analyses against MC-I activity were conducted using imaging results from 1 of 2 striata from single animal (8 monkeys total; 4 controls and 4 MPTP-treated). Degrees of each percentage reduction were calculated using mean values of normal animals for each PET probe. DA = dopamine synthesis.
Jump to section
Related Articles
Cited By...
- The relationship between brain activation and mitochondrial complex I protein levels during cognitive function in healthy humans: an [18F]BCPP-EF PET and functional MRI study of task switching
- In vivo mitochondrial and glycolytic impairments in patients with Alzheimer disease
- Effect of MPTP on Serotonergic Neuronal Systems and Mitochondrial Complex I Activity in the Living Brain: A PET Study on Conscious Rhesus Monkeys