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Research ArticleBrief Communications

The 5-HT1A Receptor PET Radioligand 11C-CUMI-101 Has Significant Binding to α1-Adrenoceptors in Human Cerebellum, Limiting Its Use as a Reference Region

Stal S. Shrestha, Jeih-San Liow, Kimberly Jenko, Masamichi Ikawa, Sami S. Zoghbi and Robert B. Innis
Journal of Nuclear Medicine December 2016, 57 (12) 1945-1948; DOI: https://doi.org/10.2967/jnumed.116.174151
Stal S. Shrestha
Molecular Imaging Branch, National Institute of Mental Health Intramural Research Program, Bethesda, Maryland
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Jeih-San Liow
Molecular Imaging Branch, National Institute of Mental Health Intramural Research Program, Bethesda, Maryland
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Kimberly Jenko
Molecular Imaging Branch, National Institute of Mental Health Intramural Research Program, Bethesda, Maryland
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Masamichi Ikawa
Molecular Imaging Branch, National Institute of Mental Health Intramural Research Program, Bethesda, Maryland
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Sami S. Zoghbi
Molecular Imaging Branch, National Institute of Mental Health Intramural Research Program, Bethesda, Maryland
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Robert B. Innis
Molecular Imaging Branch, National Institute of Mental Health Intramural Research Program, Bethesda, Maryland
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Article Information

vol. 57 no. 12 1945-1948
DOI 
https://doi.org/10.2967/jnumed.116.174151
PubMed 
27587705

Published By 
Society of Nuclear Medicine
Print ISSN 
0161-5505
Online ISSN 
2159-662X
History 
  • Received for publication February 16, 2016
  • Accepted for publication July 19, 2016
  • Published online December 1, 2016.

Article Versions

  • previous version (September 1, 2016 - 06:48).
  • You are viewing the most recent version of this article.
Copyright & Usage 
© 2016 by the Society of Nuclear Medicine and Molecular Imaging, Inc.

Author Information

  1. Stal S. Shrestha,
  2. Jeih-San Liow,
  3. Kimberly Jenko,
  4. Masamichi Ikawa,
  5. Sami S. Zoghbi and
  6. Robert B. Innis
  1. Molecular Imaging Branch, National Institute of Mental Health Intramural Research Program, Bethesda, Maryland
  1. For correspondence or reprints contact: Stal Shrestha, National Institutes of Health, 10 Center Dr., B1D43, Bethesda, MD 20892. E-mail: stal.shrestha{at}nih.gov
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Journal of Nuclear Medicine: 57 (12)
Journal of Nuclear Medicine
Vol. 57, Issue 12
December 1, 2016
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The 5-HT1A Receptor PET Radioligand 11C-CUMI-101 Has Significant Binding to α1-Adrenoceptors in Human Cerebellum, Limiting Its Use as a Reference Region
Stal S. Shrestha, Jeih-San Liow, Kimberly Jenko, Masamichi Ikawa, Sami S. Zoghbi, Robert B. Innis
Journal of Nuclear Medicine Dec 2016, 57 (12) 1945-1948; DOI: 10.2967/jnumed.116.174151

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The 5-HT1A Receptor PET Radioligand 11C-CUMI-101 Has Significant Binding to α1-Adrenoceptors in Human Cerebellum, Limiting Its Use as a Reference Region
Stal S. Shrestha, Jeih-San Liow, Kimberly Jenko, Masamichi Ikawa, Sami S. Zoghbi, Robert B. Innis
Journal of Nuclear Medicine Dec 2016, 57 (12) 1945-1948; DOI: 10.2967/jnumed.116.174151
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Keywords

  • autoradiography
  • 5-HT1A receptor
  • CUMI-101
  • cerebellum
  • α1-adrenoceptor
  • cross-reactivity
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