In Vivo Imaging of Human 11C-Metformin in Peripheral Organs: Dosimetry, Biodistribution, and Kinetic Analyses

Lars C. Gormsen; Elias Immanuel Sundelin; Jonas Brorson Jensen; Mikkel Holm Vendelbo; Steen Jakobsen; Ole Lajord Munk; Mette Marie Hougaard Christensen; Kim Brøsen; Jørgen Frøkiær; Niels Jessen

doi:10.2967/jnumed.116.177774

Research ArticleClinical Investigations

In Vivo Imaging of Human ¹¹C-Metformin in Peripheral Organs: Dosimetry, Biodistribution, and Kinetic Analyses

Lars C. Gormsen, Elias Immanuel Sundelin, Jonas Brorson Jensen, Mikkel Holm Vendelbo, Steen Jakobsen, Ole Lajord Munk, Mette Marie Hougaard Christensen, Kim Brøsen, Jørgen Frøkiær and Niels Jessen

Journal of Nuclear Medicine December 2016, 57 (12) 1920-1926; DOI: https://doi.org/10.2967/jnumed.116.177774

Lars C. Gormsen

1Department of Nuclear Medicine & PET Center, Aarhus University Hospital, Aarhus, Denmark

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Elias Immanuel Sundelin

2Department of Clinical Medicine, Aarhus University Hospital, Aarhus, Denmark

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Jonas Brorson Jensen

1Department of Nuclear Medicine & PET Center, Aarhus University Hospital, Aarhus, Denmark

2Department of Clinical Medicine, Aarhus University Hospital, Aarhus, Denmark

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Mikkel Holm Vendelbo

1Department of Nuclear Medicine & PET Center, Aarhus University Hospital, Aarhus, Denmark

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Steen Jakobsen

1Department of Nuclear Medicine & PET Center, Aarhus University Hospital, Aarhus, Denmark

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Ole Lajord Munk

1Department of Nuclear Medicine & PET Center, Aarhus University Hospital, Aarhus, Denmark

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Mette Marie Hougaard Christensen

3Department of Clinical Biochemistry and Pharmacology, Odense University Hospital, Odense, Denmark

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Kim Brøsen

3Department of Clinical Biochemistry and Pharmacology, Odense University Hospital, Odense, Denmark

4Department of Public Health, Clinical Pharmacology, University of Southern Denmark, Odense, Denmark; and

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Jørgen Frøkiær

1Department of Nuclear Medicine & PET Center, Aarhus University Hospital, Aarhus, Denmark

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Niels Jessen

2Department of Clinical Medicine, Aarhus University Hospital, Aarhus, Denmark

5Department of Clinical Pharmacology, Aarhus University Hospital, Aarhus, Denmark

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Journal of Nuclear Medicine

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December 1, 2016

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In Vivo Imaging of Human ¹¹C-Metformin in Peripheral Organs: Dosimetry, Biodistribution, and Kinetic Analyses

Lars C. Gormsen, Elias Immanuel Sundelin, Jonas Brorson Jensen, Mikkel Holm Vendelbo, Steen Jakobsen, Ole Lajord Munk, Mette Marie Hougaard Christensen, Kim Brøsen, Jørgen Frøkiær, Niels Jessen

Journal of Nuclear Medicine Dec 2016, 57 (12) 1920-1926; DOI: 10.2967/jnumed.116.177774

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In Vivo Imaging of Human ¹¹C-Metformin in Peripheral Organs: Dosimetry, Biodistribution, and Kinetic Analyses

Lars C. Gormsen, Elias Immanuel Sundelin, Jonas Brorson Jensen, Mikkel Holm Vendelbo, Steen Jakobsen, Ole Lajord Munk, Mette Marie Hougaard Christensen, Kim Brøsen, Jørgen Frøkiær, Niels Jessen

Journal of Nuclear Medicine Dec 2016, 57 (12) 1920-1926; DOI: 10.2967/jnumed.116.177774

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Keywords

metformin
11C-metformin
PET/CT
biodistribution

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In Vivo Imaging of Human ¹¹C-Metformin in Peripheral Organs: Dosimetry, Biodistribution, and Kinetic Analyses

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