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Research ArticleBasic Science Investigations

A Cystine Knot Peptide Targeting Integrin αvβ6 for Photoacoustic and Fluorescence Imaging of Tumors in Living Subjects

Chao Zhang, Richard Kimura, Lotfi Abou-Elkacem, Jelena Levi, Lingyun Xu and Sanjiv Sam Gambhir
Journal of Nuclear Medicine October 2016, 57 (10) 1629-1634; DOI: https://doi.org/10.2967/jnumed.115.169383
Chao Zhang
1Department of Radiology, Molecular Imaging Program at Stanford, Canary Center for Cancer Early Detection, Stanford University, Stanford, California; and
2Department of Medical Ultrasound, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
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Richard Kimura
1Department of Radiology, Molecular Imaging Program at Stanford, Canary Center for Cancer Early Detection, Stanford University, Stanford, California; and
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Lotfi Abou-Elkacem
1Department of Radiology, Molecular Imaging Program at Stanford, Canary Center for Cancer Early Detection, Stanford University, Stanford, California; and
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Jelena Levi
1Department of Radiology, Molecular Imaging Program at Stanford, Canary Center for Cancer Early Detection, Stanford University, Stanford, California; and
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Lingyun Xu
1Department of Radiology, Molecular Imaging Program at Stanford, Canary Center for Cancer Early Detection, Stanford University, Stanford, California; and
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Sanjiv Sam Gambhir
1Department of Radiology, Molecular Imaging Program at Stanford, Canary Center for Cancer Early Detection, Stanford University, Stanford, California; and
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Article Information

vol. 57 no. 10 1629-1634
DOI 
https://doi.org/10.2967/jnumed.115.169383
PubMed 
27230926

Published By 
Society of Nuclear Medicine
Print ISSN 
0161-5505
Online ISSN 
2159-662X
History 
  • Received for publication November 10, 2015
  • Accepted for publication April 14, 2016
  • Published online October 3, 2016.

Article Versions

  • previous version (May 26, 2016 - 05:59).
  • You are viewing the most recent version of this article.
Copyright & Usage 
© 2016 by the Society of Nuclear Medicine and Molecular Imaging, Inc.

Author Information

  1. Chao Zhang1,2,
  2. Richard Kimura1,
  3. Lotfi Abou-Elkacem1,
  4. Jelena Levi1,
  5. Lingyun Xu1 and
  6. Sanjiv Sam Gambhir1
  1. 1Department of Radiology, Molecular Imaging Program at Stanford, Canary Center for Cancer Early Detection, Stanford University, Stanford, California; and
  2. 2Department of Medical Ultrasound, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
  1. For correspondence or reprints contact: Sanjiv Sam Gambhir, Molecular Imaging Program at Stanford, James H. Clark Center, 318 Campus Dr., Stanford, CA 94305-5427. E-mail: sgambhir{at}stanford.edu
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Journal of Nuclear Medicine: 57 (10)
Journal of Nuclear Medicine
Vol. 57, Issue 10
October 1, 2016
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A Cystine Knot Peptide Targeting Integrin αvβ6 for Photoacoustic and Fluorescence Imaging of Tumors in Living Subjects
Chao Zhang, Richard Kimura, Lotfi Abou-Elkacem, Jelena Levi, Lingyun Xu, Sanjiv Sam Gambhir
Journal of Nuclear Medicine Oct 2016, 57 (10) 1629-1634; DOI: 10.2967/jnumed.115.169383

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A Cystine Knot Peptide Targeting Integrin αvβ6 for Photoacoustic and Fluorescence Imaging of Tumors in Living Subjects
Chao Zhang, Richard Kimura, Lotfi Abou-Elkacem, Jelena Levi, Lingyun Xu, Sanjiv Sam Gambhir
Journal of Nuclear Medicine Oct 2016, 57 (10) 1629-1634; DOI: 10.2967/jnumed.115.169383
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  • SPECT/CT imaging, biodistribution and radiation dosimetry of a 177Lu-DOTA-integrin {alpha}v{beta}6 cystine knot peptide in a pancreatic cancer xenograft model
  • Recent Development of Technology and Application of Photoacoustic Molecular Imaging Toward Clinical Translation
  • Development and Preclinical Validation of a Cysteine Knottin Peptide Targeting Integrin {alpha}v{beta}6 for Near-infrared Fluorescent-guided Surgery in Pancreatic Cancer
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Keywords

  • photoacoustic fluorescence imaging
  • integrin αvβ6
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