Article Figures & Data
Figures
- FIGURE 1.
HRRT average image (A) and HR average image (B) obtained using selected optimal acquisition time window. Axial images are at level of striatum and midbrain (SN).
- FIGURE 2.
Linear regression analysis of WAPI BPND and SBR calculated on average images obtained using selected time window (from min 16.5 to 42), on HRRT and simulated HR systems.
- FIGURE 3.
Linear regression analysis of WAPI BPND and SBRHR in controls and PD patients. SBRHR was obtained from average images using selected time window.
- FIGURE 4.
Linear regression analysis of SBRHR and WAPI BPND for controls (A) and PD patients (B) in all regions examined. SBRHR was obtained from average images using selected time window.
Tables
Group Age Sex MMSE Disease duration (y) H-Y stage UPDRS motor LEDs Controls 60.3 ± 7 9 M/1F 29.4 ± 1 NA NA NA NA PD patients 60.2 ± 9 9 M/1F 28.7 ± 1 3.1 ± 4 1.4 18.9 ± 7 348.6 ± 268 Data are mean ± SD.
MMSE = Mini-Mental State Examination; H-Y stage = Hoehn and Yahr stage; UPDRS = Unified Parkinson's Disease Rating Scale; LED = Levodopa-equivalent dose; NA = not applicable.
Time window (min) r2 Linear regression equation (WAPI BPND – SBRdyn) Difference between outcome measures in Bland–Altman plots (mean ± SD) Bland–Altman plot slope (WAPI BPND – SBRdyn) SBR I (16.5–42) 0.98 y = 0.85x + 0.21 0.13 ± 0.29 0.15 SBR II (42–66) 0.97 y = 1.47x + 0.03 −1.06 ± 0.80 −0.40 SBR III (66–90) 0.90 y = 1.60x + 0.33 −1.08 ± 1.18 −0.52 SBR IV (10.5–19.5) 0.91 y = 0.44x + 0.16 1.25 ± 0.88 0.81 SBR V (19.5–30) 0.97 y = 0.74x + 0.25 0.36 ± 0.43 0.29 SBR VI (30–42) 0.99 y = 1.13x + 0.21 −0.52 ± 0.32 −0.14 SBR VII (13.5–36) 0.97 y = 0.70x + 0.21 0.50 ± 0.48 0.34 SBR VIII (13.5–42) 0.98 y = 0.78x + 0.19 0.31 ± 0.37 0.23 r2 = linear regression equation, difference between outcome measures in Bland–Altman plots and slope of Bland–Altman plots.
- TABLE 3
Percentage Difference Between WAPI BPND and SBR values (SBRHRRT and SBRHR) in Controls and PD Patients
Controls PD patients % difference SBRHRRT SBRHR SBRHRRT SBRHR Caudate 18.0% 40.0% 15.4% 38.4% Putamen 20.8% 36.0% 6.4% 19.4% Ventral striatum 16.5% 34.5% 11.6% 30.4% SN −5.1% 22.3% −11.2% 14.6% Effect size Caudate Putamen Ventral striatum SN SBRHRRT 0.60 1.48 0.66 0.38 SBRHR 0.56 1.40 0.63 0.38 WAPI BPND 0.65 1.70 0.69 0.49 SRTM 0.66 1.60 0.62 0.53 LoganRef 0.62 1.57 0.61 0.49
Supplemental Data
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