Research ArticleBasic Science Investigations

Retention Kinetics of the 18F-Labeled Sympathetic Nerve PET Tracer LMI1195: Comparison with 11C-Hydroxyephedrine and 123I-MIBG

Rudolf A. Werner, Christoph Rischpler, David Onthank, Constantin Lapa, Simon Robinson, Samuel Samnick, Mehrbod Javadi, Markus Schwaiger, Stephan G. Nekolla and Takahiro Higuchi
Journal of Nuclear Medicine September 2015, 56 (9) 1429-1433; DOI: https://doi.org/10.2967/jnumed.115.158493

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  • FIGURE 1.
    FIGURE 1.

    Chemical structures of the neurotransmitter norepinephrine, the sympathetic nerve radiotracer 18F-LMI1195, and the conventional tracers 123I-MIBG and 11C-hydroxyephedrine (11C-HED).

  • FIGURE 2.
    FIGURE 2.

    Averaged time–activity curves and representative short-axis images of in vivo rabbit cardiac PET imaging. Desipramine (DMI) chase enhanced 11C-hydroxyephedrine (11C-HED) washout from heart, whereas 18F-LMI1195 washout did not change.

  • FIGURE 3.
    FIGURE 3.

    Results of in vivo rabbit 123I-MIBG planar scintigraphy of chest. Desipramine (DMI) chase did not change cardiac distribution of 123I-MIBG. Dotted lines indicate regions of interest in heart and mediastinum. H/M ratio = heart-to-mediastinum ratio.

  • FIGURE 4.
    FIGURE 4.

    Simplified schematic of 11C-hydroxyephedrine (11C-HED), 123I-MIBG, and 18F-LMI1195 kinetics at nerve terminals. After transportation into nerve terminals via uptake-1 NET system, 11C-hydroxyephedrine retention is maintained by continuous uptake-1 activity, whereas 18F-LMI1195 and 123I-MIBG seem to be stored stably at nerve terminals.

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