Article Figures & Data
Figures
- FIGURE 1.
General structure of bis(thiosemicarbazones). 64Cu-ATS: R1 = R2 = CH3, R3 = R4 = H; 64Cu-ATSM = R1 = R2 = R3 = CH3, R4 = H; 64Cu-CTS = R1 = C2H5, R2 = CH3, R3 = R4 = H; 64Cu-ATSE: R1 = R2 = R3 = R4 = CH3.
- FIGURE 2.
Relationship between hypoxic buffer perfusion and 64Cu radiotracer uptake. Data (mean n = 6 ± SD) represent cardiac 64Cu retention from 64Cu-CTS, 64Cu-ATS, 64Cu-ATSE, and 64Cu-ATSM as %ID 10 min after injection after 5 min of hypoxia (A) and after 25 min of hypoxia (B). *Significantly different from prehypoxic control values (P < 0.05).
- FIGURE 3.
Relationship between hypoxic buffer perfusion and cardiac contractility and hemodynamics. Data (mean n = 6 ± SD) represent changes in left ventricular developed pressure, left ventricular end-diastolic pressure, and perfusion pressure (PP) after 5 min of hypoxia (A) and after 25 min of hypoxia (B). *Significantly different from prehypoxic values (P < 0.05).
- FIGURE 4.
(A) Representative 31P nuclear MR spectra showing changes in cardiac energetics during perfusion with 0% O2 buffer. (B and C) Relationship between hypoxic buffer perfusion and cardiac energetics. Data mean (n = 6 ± SD) represents changes in phosphocreatine (PCr), ATP, inorganic phosphate (Pi), and sugar phosphates after 5 min and 25 min of hypoxia. *Significantly different from prehypoxic values (P < 0.05).
- FIGURE 5.
(A) Relationship between hypoxic buffer perfusion and lactate washout after 5 min and 25 min of hypoxia. (B) HIF-1α expression at end of each perfusion protocol. Data are mean values (n = 6) ± SD. *Significantly different from prehypoxic values (P < 0.05).
