Article Figures & Data
Figures
- FIGURE 1.
Statistical maps used to calculate expression values. (A) T-contrast AD versus CON. (B) T-contrast PD versus CON. Statistical maps were shown with threshold of uncorrected P value < 0.001 and overlaid onto single subject T1 template.
- FIGURE 2.
Metabolic topological map. (A) Statistical maps used to calculate expression values correspond to group t-contrasts: AD < CON and PD < CON. (B) Positions of group means in normalized/whitened PC space. (C) Distribution in overall normalized feature space (aligned and scaled along 2 PCs, PCcog and PCmot) with colored area inside isocurve of constant feature density for each of our patient groups.
- FIGURE 3.
Correlation between PCs and clinical scores. Projections to PCs have strong negative correlation with MMSE (PCcog) and strong positive correlation with motor UPDRS III scale (PCmot). Decomposition/whitening according to PC of original datasets allows differentiation of clinical symptoms cognitive deficits and motor deficits based on their metabolic patterns.
- FIGURE 4.
Visualization of principal patterns PCcog and PCmot. (A) Pattern related to PCcog demonstrating high negative correlation with dementia score (MMSE). (B) Pattern related to PCmot demonstrating high positive correlation with motor score (UPDRS III). Blue/cyan are regions in which rCMRglc measurements positively correlated with cognitive (A) or motor (B) capabilities, whereas red/yellow are regions in which these capabilities were negatively coupled with rCMRglc.
Tables
Group n Sex (M/F) Mean age Mean MMSE Mean UPDRS III AD 91 46/45 69.47 (7.78) 22.51 (4.25) — CON 24 12/12 69.92 (6.30) 29.38 (0.82) 0.3 (0.68)* DLB 26 14/12 71.73 (6.50) 21.54 (5.34) 26.77 (15.01) MCI 100 51/49 65.79 (9.06) 27.18 (2.00) — PD 20 14/6 67.65 (9.27) 28.25 (1.21) 30.65 (10.93) PDD 17 14/3 70.76 (7.34) 21.41 (3.71) 40.71 (14.23) ↵* Only n = 10 UPDRS III measurements were available for CON group.
Data in parentheses are SDs.
AD MCI CON DLB PDD PD MMSE UPDRS III MMSE UPDRS III MMSE UPDRS III MMSE UPDRS III MMSE UPDRS III MMSE UPDRS III AD * — * — NS — NS — * — MCI * NS * — * — * — † — CON * NS * NS * — * — ‡ — DLB NS * * * * * NS ‡ * NS PDD NS * * * * * NS NS * † PD * * NS * * * * ‡ * NS PCcog PCmot PCcog PCmot PCcog PCmot PCcog PCmot PCcog PCmot PCcog PCmot Post hoc tests (based on Wilcoxon tests) calculated separately on the 2 clinical scores, MMSE and UPDRS III (top-right/gray), and the 2 features, PCcog and PCmot (bottom-left/white), between all groups. Comparison between PDD and DLB (bold) is the only combination that showed insufficient group differences in both topological feature dimensions. Range of P values is indicated by the following: †P < 0.05; ‡P < 0.01; *P < 0.001.
— = clinical score not available; NS = no significant difference.
Supplemental Data
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