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Research ArticleClinical Investigations

Dose-Finding Quantitative 18F-FDG PET Imaging Study with the Oral Pan-AKT Inhibitor GSK2141795 in Patients with Gynecologic Malignancies

Hatice Gungor, Azeem Saleem, Syed Babar, Roberto Dina, Mona A. El-Bahrawy, Ed Curry, Nona Rama, Michele Chen, Emily Pickford, Roshan Agarwal, Sarah Blagden, Sabin Carme, Cristian Salinas, Sam Madison, Elizabeth Krachey, Ademi Santiago-Walker, Deborah A. Smith, Shannon R. Morris, Euan A. Stronach and Hani Gabra
Journal of Nuclear Medicine December 2015, 56 (12) 1828-1835; DOI: https://doi.org/10.2967/jnumed.115.156505
Hatice Gungor
1Ovarian Cancer Action Research Centre, Department of Surgery and Cancer, Imperial College London, London, United Kingdom
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Azeem Saleem
2Imanova Centre for Imaging Sciences (formerly GSK Clinical Imaging Centre), Hammersmith Hospital, London, United Kingdom
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Syed Babar
3Department of Radiology, Imperial College Healthcare NHS Trust, London, United Kingdom
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Roberto Dina
4Department of Histopathology, Imperial College London, London, United Kingdom
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Mona A. El-Bahrawy
4Department of Histopathology, Imperial College London, London, United Kingdom
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Ed Curry
1Ovarian Cancer Action Research Centre, Department of Surgery and Cancer, Imperial College London, London, United Kingdom
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Nona Rama
1Ovarian Cancer Action Research Centre, Department of Surgery and Cancer, Imperial College London, London, United Kingdom
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Michele Chen
1Ovarian Cancer Action Research Centre, Department of Surgery and Cancer, Imperial College London, London, United Kingdom
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Emily Pickford
1Ovarian Cancer Action Research Centre, Department of Surgery and Cancer, Imperial College London, London, United Kingdom
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Roshan Agarwal
1Ovarian Cancer Action Research Centre, Department of Surgery and Cancer, Imperial College London, London, United Kingdom
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Sarah Blagden
1Ovarian Cancer Action Research Centre, Department of Surgery and Cancer, Imperial College London, London, United Kingdom
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Sabin Carme
5AVIESAN, Strategic Valorization, Paris, France
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Cristian Salinas
2Imanova Centre for Imaging Sciences (formerly GSK Clinical Imaging Centre), Hammersmith Hospital, London, United Kingdom
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Sam Madison
6GlaxoSmithKline, Collegeville, Pennsylvania and Research Triangle Park, North Carolina; and
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Elizabeth Krachey
6GlaxoSmithKline, Collegeville, Pennsylvania and Research Triangle Park, North Carolina; and
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Ademi Santiago-Walker
6GlaxoSmithKline, Collegeville, Pennsylvania and Research Triangle Park, North Carolina; and
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Deborah A. Smith
6GlaxoSmithKline, Collegeville, Pennsylvania and Research Triangle Park, North Carolina; and
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Shannon R. Morris
7MedImmune, AstraZeneca, Gaithersburg, Maryland
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Euan A. Stronach
1Ovarian Cancer Action Research Centre, Department of Surgery and Cancer, Imperial College London, London, United Kingdom
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Hani Gabra
1Ovarian Cancer Action Research Centre, Department of Surgery and Cancer, Imperial College London, London, United Kingdom
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Article Information

vol. 56 no. 12 1828-1835
DOI 
https://doi.org/10.2967/jnumed.115.156505
PubMed 
26429956

Published By 
Society of Nuclear Medicine
Print ISSN 
0161-5505
Online ISSN 
2159-662X
History 
  • Received for publication February 25, 2015
  • Accepted for publication September 21, 2015
  • Published online December 1, 2015.

Article Versions

  • previous version (October 1, 2015 - 08:02).
  • You are viewing the most recent version of this article.
Copyright & Usage 
© 2015 by the Society of Nuclear Medicine and Molecular Imaging, Inc.

Author Information

  1. Hatice Gungor1,
  2. Azeem Saleem2,
  3. Syed Babar3,
  4. Roberto Dina4,
  5. Mona A. El-Bahrawy4,
  6. Ed Curry1,
  7. Nona Rama1,
  8. Michele Chen1,
  9. Emily Pickford1,
  10. Roshan Agarwal1,
  11. Sarah Blagden1,
  12. Sabin Carme5,
  13. Cristian Salinas2,
  14. Sam Madison6,
  15. Elizabeth Krachey6,
  16. Ademi Santiago-Walker6,
  17. Deborah A. Smith6,
  18. Shannon R. Morris7,
  19. Euan A. Stronach1 and
  20. Hani Gabra1
  1. 1Ovarian Cancer Action Research Centre, Department of Surgery and Cancer, Imperial College London, London, United Kingdom
  2. 2Imanova Centre for Imaging Sciences (formerly GSK Clinical Imaging Centre), Hammersmith Hospital, London, United Kingdom
  3. 3Department of Radiology, Imperial College Healthcare NHS Trust, London, United Kingdom
  4. 4Department of Histopathology, Imperial College London, London, United Kingdom
  5. 5AVIESAN, Strategic Valorization, Paris, France
  6. 6GlaxoSmithKline, Collegeville, Pennsylvania and Research Triangle Park, North Carolina; and
  7. 7MedImmune, AstraZeneca, Gaithersburg, Maryland
  1. For correspondence or reprints contact: Hatice Gungor, Ovarian Cancer Action Research Centre, Department of Surgery and Cancer, Imperial College London, London, U.K. E-mail: h.gungor{at}imperial.ac.uk
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Journal of Nuclear Medicine: 56 (12)
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Dose-Finding Quantitative 18F-FDG PET Imaging Study with the Oral Pan-AKT Inhibitor GSK2141795 in Patients with Gynecologic Malignancies
Hatice Gungor, Azeem Saleem, Syed Babar, Roberto Dina, Mona A. El-Bahrawy, Ed Curry, Nona Rama, Michele Chen, Emily Pickford, Roshan Agarwal, Sarah Blagden, Sabin Carme, Cristian Salinas, Sam Madison, Elizabeth Krachey, Ademi Santiago-Walker, Deborah A. Smith, Shannon R. Morris, Euan A. Stronach, Hani Gabra
Journal of Nuclear Medicine Dec 2015, 56 (12) 1828-1835; DOI: 10.2967/jnumed.115.156505

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Dose-Finding Quantitative 18F-FDG PET Imaging Study with the Oral Pan-AKT Inhibitor GSK2141795 in Patients with Gynecologic Malignancies
Hatice Gungor, Azeem Saleem, Syed Babar, Roberto Dina, Mona A. El-Bahrawy, Ed Curry, Nona Rama, Michele Chen, Emily Pickford, Roshan Agarwal, Sarah Blagden, Sabin Carme, Cristian Salinas, Sam Madison, Elizabeth Krachey, Ademi Santiago-Walker, Deborah A. Smith, Shannon R. Morris, Euan A. Stronach, Hani Gabra
Journal of Nuclear Medicine Dec 2015, 56 (12) 1828-1835; DOI: 10.2967/jnumed.115.156505
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Keywords

  • FDG-PET
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