Abstract
1545
Objectives To evaluate the false negative rate(FNR) and sensitivity of periareolar injections in patients (pts) with breast cancer, underwent sentinel lymph node (SLN) scintigraphy,and also to compare Tc nanocolloid with Tc-SintiScint regarding to detection rate.
Methods 503 pts were included.The day before surgery, SLN was performed, after intradermal injection of mean 51 MBq activity of Tc nanocolloid or Tc-SintiScint in four multiple injections.After operation pts were followed up.The calculation of the sensitivity and FNR of the SLN biopsy was done on the basis of the results of the follow-up examinations.
Results The mean age was 57 years. 416 pts had a singular and 87 pts had multifocal tumours. Most pts had an invasive ductal carcinoma. In 302 pts SLN scintigraphy was performed with Tc-Nanocolloid and in 201 with Tc-SintiScint. There was no significant difference between Nanocolloid and Scintiscint regarding the identification rate of SLN with gamma probe during operation (p=0.3) and the number of pathologic lymph nodes (p=0.43).The identification rate with gamma probe during operation was 96.6 %. In 486 pts at least one SLN could be found during the operation. Altogether, 1202 SLN were harvested. 118 pts (118/486) had metastases.360 pts with at least 1 year follow-up were included for the calculation of FNR and sensitivity of SLNB.The mean follow-up was 36 months.The sensitivity and FNR of SLNB were 100 % and 0,respectively.
Conclusions In patients with breast cancer SLN scintigraphy with periareolar injections is a method with high sensitivity and very low FNR. In this study there was no significant difference between 99mTc-Nanocolloid and 99mTc-SintiScint regarding identification rate.