Article Figures & Data
Figures
- FIGURE 1.
Multiparametric PET/CT of CRC comprising 18F-FDG uptake image (A), CT image with positive texture features highlighted by filter shaded green (B), CT texture histogram (C), and CT perfusion image (D). Corresponding values are: SUVmax, 10.7; MPP, 12.3; BF, 53.1 mL/min/100 g (text provides methods of derivation).
- FIGURE 2.
Diagnostic performance values for each modality separately, compared with decision tree.
- FIGURE 3.
Summary of decision tree. Numbers in parentheses indicate number of tumors passing along each pathway.
Tables
Imaging dataset Tumor feature Quantifier 18F-FDG PET emission 18F-FDG uptake SUVmax Low-dose unenhanced CT Texture MPP DCE CT Vascularity BF Imaging characteristic Mean Range Tumor area (cm2) 11.2 3.5–29.3 SUVmax 18.4 4.5–47.1 MPP 21.6 9.3–138.1 BF (mL/min/100 mL) 77.0 40.5–153.3 - TABLE 3
TPRs and FPRs for Each Decision Node and Entire Decision Tree Along with Their Respective 95% CIs
SUV > 16 MPP ≤ 17.5 (when SUV > 16) MPP > 17.5 (when SUV ≤ 16) BF > 70 mL/min/100 mL (when SUV low and MPP high) Overall decision tree Parameter/threshold TPR (%) FPR (%) TPR (%) FPR (%) TPR (%) FPR (%) TPR (%) FPR (%) TPR (%) FPR (%) Baseline 52.9 31.2 100 0 75.0 36.4 83.3 0 82.4 0 95% CI 28.5–76.1 12.1–58.5 62.9–100 0–53.7 35.6–95.6 12.4–68.4 36.5–99.1 0–60.4 63.9–93.9 0–10.4 Iteration 1 49.9 32.6 100 6.0 51.9 30.2 70.1 0 68.1 1.2 Iteration 2 80.7 34.7 85.2 12.3 54.9 21.8 100 0.4 79.4 4.4 Iteration 3 57.0 27.4 100 0 59.6 65.1 80.2 0 77.5 0 Iteration 4 72.1 27.6 90.9 0 69.7 34.9 91.8 26.6 83.4 6.7 Iteration 5 61.3 13.6 96.0 0 69.0 37.2 58.4 0 74.5 0 First 5 iterations of Monte Carlo analysis are also shown.
- TABLE 4
Immunohistochemical Differences Between 2 Imaging Phenotypes Identified by Decision Tree
Imaging phenotype Hypoxia/proliferation SUV > 16, MPP ≤ 17.5 SUV ≤ 16, MPP > 17.5, BF > 70 mL/min/mL HIF-1 (−)/mcm2 (−) 0 0 HIF-1 (−)/mcm2 (+) 2 4 HIF-1 (+)/mcm2(−) 4 0 HIF-1 (+)/mcm2 (+) 3 1
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