Article Figures & Data
Figures
- FIGURE 1.
Temporal evolution of individual SUVs measured at YNHH for injected 18F-FDG doses of 3.3–4.8 MBq/kg (0.10–0.13 mCi/kg). SUV data are normalized to 180-s time point.
- FIGURE 2.
Temporal evolution of individual SUVs measured at YNHH for injected 18F-FDG doses of 5.2–8.5 MBq/kg (0.14–0.2 mCi/kg). SUV data are normalized to 180-s time point.
- FIGURE 3.
Temporal evolution of individual SUVs measured at CNR/FTGM for injected 18F-FDG doses of 4.4–4.8 MBq/kg (0.12–0.13 mCi/kg). SUV data are normalized to 180-s time point.
- FIGURE 4.
Temporal evolution of all SUVs collectively. Individual SUV at each time point was normalized to SUV at 180-s time point in each group, before determination of SD.
Tables
Demographic Phase 1 (555 MBq) YNHH Phase 2 (370 MBq) YNHH Phase 2 (3.7 MBq/kg) CNR/FTGM Sex (F/M) 25/26 25/18 14/12 Age (y) 56.5 ± 18.8 (13–85) 63.2 ± 14.1 (20–92) 60.8 ± 13.4 (23–79) Body mass index (kg/m2) 29.0 ± 8.5 (16.4–62.0) 27.5 ± 6.6 (16.3–47.8) 25.7 ± 3.9 (19.5–31.1) Dose mCi 15.1 ± 1.7 (10.7–19.2) 10.4 ± 0.9 (8.4–12.9) 8.2 ± 1.3 (5.4–10.6) MBq 559 ± 62.8 (396–711) 383 ± 34.9 (311–478) 303 ± 49.1 (201–392) Dose/kg mCi/kg 0.21 ± 0.07 (0.08–0.39) 0.14 ± 0.03 (0.09–0.23) 0.11 ± 0.01 (0.10–0.16) MBq/kg 7.8 ± 2.4 (3.1–14.4) 5.2 ± 1.3 (3.3–8.5) 4.1 ± 0.5 (3.6–5.8) Blood glucose (mg/dL) 117.5 ± 30.2 (57–226) 110.7 ± 16.3 (76–153) 100.7 ± 10.6 (77–136) Uptake time (min) 67.7 ± 10.3 (54–107) 66.4 ± 8.0 (50–91) 63.6 ± 7.7 (56–80) Data are average ± SD, followed by range in parentheses.
Diagnosis Phase 1 (555 MBq) YNHH Phase 2 (370 MBq) YNHH Phase 2 (3.7 MBq/kg) CNR/FTGM Lymphoma 1.4 ± 0.5 cm (0.5–2.4 cm), n = 17 1.3 ± 0.5 cm (0.6–2.5 cm), n = 10 1.2 ± 0.8 cm (0.6–2.7 cm), n = 6 Lung cancer 1.0 ± 0.4 cm (0.6–1.8 cm), n = 8 1.7 ± 0.7 cm (0.7–4.0 cm), n = 19 1.7 ± 0.8 cm (0.7–3.5 cm), n = 18 Breast cancer 2.2 ± 1.3 cm (0.5–4.3 cm), n = 4 1.4 ± 0.5 cm (0.8–2.9 cm), n = 12 1.8 ± 1.3 cm (0.9–2.7 cm), n = 2 Pancreas cancer 1.8 ± 0.7 cm (1.2–2.8 cm), n = 3 1.3 ± 0.9 cm (0.8–2.8 cm), n = 2 Not applicable Miscellaneous 1.4 ± 1.0 cm (0.4–4.5 cm), n = 19 Not applicable Not applicable Data are average ± SD, followed by range in parentheses.
- TABLE 3
Perceived Quality of PET Images (51 Scans) from Phase 1 of This Study (Prescribed 18F-FDG Dose, 555 MBq [15 mCi]) as Function of Acquisition Time
Acquisition time (s) Uninterpretable (%) Poor (%) Adequate (%) Unequivocal % 30 65 29 6 0 60 14 45 41 0 90 0 22 60 18 120 0 2 23 75 150 0 0 6 94 180 0 0 0 100 - TABLE 4
Perceived Quality of PET Images (69 Scans) from Phase 2 of This Study (Prescribed 18F-FDG Dose, 370 MBq [10 mCi] or 3.7 MBq [0.1 mCi]/kg) as Function of Acquisition Time
Acquisition time (s) Uninterpretable (%) Poor (%) Adequate (%) Unequivocal (%) 30 93 7 0 0 60 51 40 9 0 90 2 60 33 5 120 0 12 60 28 150 0 0 21 79 180 0 0 0 100 - TABLE 5
SD and P Values for Variance of Normalized SUVmax of All Plots Within Each Subcategory of Acquisition Time and Dose Range
Dose 3.3–4.1 MBq/kg (0.09–0.11 mCi/kg) 4.4–4.8 MBq/kg (0.12–0.13 mCi/kg) 5.2–5.6 MBq/kg (0.14–0.15 mCi/kg) 5.9–8.5 MBq/kg (0.16–0.23 mCi/kg) Acquisition time (s) σ P σ P σ P σ P 30 0.18 1.0E−11 0.15 3.0E−9 0.15 2.0E−16 0.11 1.0E−5 60 0.11 8.0E−8 0.09 0.0001 0.08 6.0E−11 0.07 0.004 90 0.05 0.02 0.06 0.04 0.05 6.0E−6 0.04 0.99 120 0.05 0.01 0.05 0.29 0.04 0.001 0.04 0.8 150 0.03 0.04 0.02 0.04
