PT  - JOURNAL ARTICLE
AU  - David W. Cheng
AU  - Devrim Ersahin
AU  - Lawrence H. Staib
AU  - Daniele Della Latta
AU  - Assuero Giorgetti
AU  - Francesco d’Errico
TI  - Using SUV as a Guide to <sup>18</sup>F-FDG Dose Reduction
AID  - 10.2967/jnumed.114.140129
DP  - 2014 Dec 01
TA  - Journal of Nuclear Medicine
PG  - 1998--2002
VI  - 55
IP  - 12
4099  - http://jnm.snmjournals.org/content/55/12/1998.short
4100  - http://jnm.snmjournals.org/content/55/12/1998.full
SO  - J Nucl Med2014 Dec 01; 55
AB  - This article explores how one can lower the injected 18F-FDG dose while maintaining validity in comparing standardized uptake values (SUVs) between studies. Variations of the SUV within each lesion were examined at different acquisition times. Methods: Our protocol was approved by either the Human Investigation Committee or the Institutional Review Board. All 120 PET datasets were acquired continuously for 180 s per bed position in list mode and were reconstructed to obtain 30-, 60-, 90-, 120-, 150-, and 180-s-per-bed-position PET images with registration to a single set of nondiagnostic CT images. Qualitative assessment of the images was performed separately for correlation. The SUV measurements of each lesion were computed and normalized to the 180-s acquisition values to create a stabilization factor. These stabilization factors were used to demonstrate a predictable trend of stabilization over time. The variances of the stabilization factors over the entire dataset, composed of several tumor types over a range of sizes, were compared for each time point with the corresponding 150-s time point using a 2-sided F test, which has similar values to the 180-s time point. Results: The variance of the data decreased with increasing acquisition time and with increasing dose but leveled off for sufficiently long acquisitions. Conclusion: Through the statistical analysis of SUVs for increasing acquisition times and visual evaluation of the plots, we developed and hereby propose an algorithm that can be used to seek the maximum reduction in administered 18F-FDG dose while preserving the validity of SUV comparisons.