Article Figures & Data
Figures
- FIGURE 1.
18F-FDG PET scans of hindlimbs of rat models, 8 d after denervation. (A) Images of axial, coronal, and sagittal sections are shown. PET/CT overlay fusion images are shown on right side. ROIs for each compartment are drawn in axial section of fusion image, red line for anterolateral and green line for posterior, respectively. ROIs for both upper thigh are drawn in transparent yellow circles, which cannot be drawn on provided axial image because of its rostral location. Increased radioactivities of denervated left anterolateral and posterior compartments muscles are shown. (B) LNRmax values are significantly increased at left side for both compartments. *P < 0.01.
- FIGURE 2.
Results of immunohistochemistry from both gastrocnemius muscles. (A and B) Immunohistochemistry of hexokinase II shows increased expression of hexokinase II at left (denervated) side. (C and D) Immunohistochemistry of GLUT-1 shows increased expression of GLUT-1 at left side. (E and F) Immunohistochemistry of GLUT-4 shows no definite asymmetric expression. IHC = Immunohistochemistry.
- FIGURE 3.
Results of Western blots. Normalized optical densities of hexokinase II in tibialis anterior muscle and GLUT-1 in gastrocnemius muscle are significantly increased in left (denervated) side, compared with sham-operation side. However, normalized optical densities of GLUT-4 in both gastrocnemius and tibialis anterior muscles are decreased without statistical significance. *P < 0.01.
- FIGURE 4.
Axial images of left tibial neuropathy model. Anterolateral and posterior compartment are drawn with red and green circles, respectively. Only posterior compartment muscles show increased 18F-FDG uptake, compared with Figure 1A.
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