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Research ArticleBasic Science Investigations

Distinctive In Vivo Kinetics of the New σ1 Receptor Ligands (R)-(+)- and (S)-(–)-18F-Fluspidine in Porcine Brain

Peter Brust, Winnie Deuther-Conrad, Georg Becker, Marianne Patt, Cornelius K. Donat, Shannon Stittsworth, Steffen Fischer, Achim Hiller, Barbara Wenzel, Sladjana Dukic-Stefanovic, Swen Hesse, Jörg Steinbach, Bernhard Wünsch, Susan Z. Lever and Osama Sabri
Journal of Nuclear Medicine October 2014, 55 (10) 1730-1736; DOI: https://doi.org/10.2967/jnumed.114.137562
Peter Brust
1Helmholtz-Zentrum Dresden-Rossendorf, Institute of Radiopharmaceutical Cancer Research, Leipzig, Germany
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Winnie Deuther-Conrad
1Helmholtz-Zentrum Dresden-Rossendorf, Institute of Radiopharmaceutical Cancer Research, Leipzig, Germany
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Georg Becker
2Department of Nuclear Medicine and IFB Adiposity Diseases, Universität Leipzig, Leipzig, Germany
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Marianne Patt
2Department of Nuclear Medicine and IFB Adiposity Diseases, Universität Leipzig, Leipzig, Germany
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Cornelius K. Donat
1Helmholtz-Zentrum Dresden-Rossendorf, Institute of Radiopharmaceutical Cancer Research, Leipzig, Germany
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Shannon Stittsworth
3Department of Chemistry, University of Missouri, Columbia, Missouri
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Steffen Fischer
1Helmholtz-Zentrum Dresden-Rossendorf, Institute of Radiopharmaceutical Cancer Research, Leipzig, Germany
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Achim Hiller
1Helmholtz-Zentrum Dresden-Rossendorf, Institute of Radiopharmaceutical Cancer Research, Leipzig, Germany
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Barbara Wenzel
1Helmholtz-Zentrum Dresden-Rossendorf, Institute of Radiopharmaceutical Cancer Research, Leipzig, Germany
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Sladjana Dukic-Stefanovic
1Helmholtz-Zentrum Dresden-Rossendorf, Institute of Radiopharmaceutical Cancer Research, Leipzig, Germany
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Swen Hesse
2Department of Nuclear Medicine and IFB Adiposity Diseases, Universität Leipzig, Leipzig, Germany
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Jörg Steinbach
1Helmholtz-Zentrum Dresden-Rossendorf, Institute of Radiopharmaceutical Cancer Research, Leipzig, Germany
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Bernhard Wünsch
4Department of Pharmaceutical and Medicinal Chemistry, Westfälische Wilhelms-Universität Münster, Münster, Germany; and
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Susan Z. Lever
3Department of Chemistry, University of Missouri, Columbia, Missouri
5MU Research Reactor, University of Missouri, Columbia, Missouri
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Osama Sabri
2Department of Nuclear Medicine and IFB Adiposity Diseases, Universität Leipzig, Leipzig, Germany
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Article Information

vol. 55 no. 10 1730-1736
DOI 
https://doi.org/10.2967/jnumed.114.137562
PubMed 
25071097

Published By 
Society of Nuclear Medicine
Print ISSN 
0161-5505
Online ISSN 
2159-662X
History 
  • Received for publication January 27, 2014
  • Accepted for publication April 22, 2014
  • Published online October 1, 2014.

Article Versions

  • previous version (July 28, 2014 - 06:19).
  • You are viewing the most recent version of this article.
Copyright & Usage 
© 2014 by the Society of Nuclear Medicine and Molecular Imaging, Inc.

Author Information

  1. Peter Brust*,1,
  2. Winnie Deuther-Conrad*,1,
  3. Georg Becker2,
  4. Marianne Patt2,
  5. Cornelius K. Donat1,
  6. Shannon Stittsworth3,
  7. Steffen Fischer1,
  8. Achim Hiller1,
  9. Barbara Wenzel1,
  10. Sladjana Dukic-Stefanovic1,
  11. Swen Hesse2,
  12. Jörg Steinbach1,
  13. Bernhard Wünsch4,
  14. Susan Z. Lever3,5 and
  15. Osama Sabri2
  1. 1Helmholtz-Zentrum Dresden-Rossendorf, Institute of Radiopharmaceutical Cancer Research, Leipzig, Germany
  2. 2Department of Nuclear Medicine and IFB Adiposity Diseases, Universität Leipzig, Leipzig, Germany
  3. 3Department of Chemistry, University of Missouri, Columbia, Missouri
  4. 4Department of Pharmaceutical and Medicinal Chemistry, Westfälische Wilhelms-Universität Münster, Münster, Germany; and
  5. 5MU Research Reactor, University of Missouri, Columbia, Missouri
  1. For correspondence or reprints contact: Peter Brust, Helmholtz-Zentrum Dresden-Rossendorf, Institute of Radiopharmaceutical Cancer Research, Permoserstrasse 15, 04318 Leipzig, Germany. E-mail: p.brust{at}hzdr.de
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Journal of Nuclear Medicine: 55 (10)
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Distinctive In Vivo Kinetics of the New σ1 Receptor Ligands (R)-(+)- and (S)-(–)-18F-Fluspidine in Porcine Brain
Peter Brust, Winnie Deuther-Conrad, Georg Becker, Marianne Patt, Cornelius K. Donat, Shannon Stittsworth, Steffen Fischer, Achim Hiller, Barbara Wenzel, Sladjana Dukic-Stefanovic, Swen Hesse, Jörg Steinbach, Bernhard Wünsch, Susan Z. Lever, Osama Sabri
Journal of Nuclear Medicine Oct 2014, 55 (10) 1730-1736; DOI: 10.2967/jnumed.114.137562

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Distinctive In Vivo Kinetics of the New σ1 Receptor Ligands (R)-(+)- and (S)-(–)-18F-Fluspidine in Porcine Brain
Peter Brust, Winnie Deuther-Conrad, Georg Becker, Marianne Patt, Cornelius K. Donat, Shannon Stittsworth, Steffen Fischer, Achim Hiller, Barbara Wenzel, Sladjana Dukic-Stefanovic, Swen Hesse, Jörg Steinbach, Bernhard Wünsch, Susan Z. Lever, Osama Sabri
Journal of Nuclear Medicine Oct 2014, 55 (10) 1730-1736; DOI: 10.2967/jnumed.114.137562
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