Abstract
1682
Objectives The purpose of our study was to determine the effect of Anti-inflammatory therapy (AIT) on FDG SUV and LVEF and determine the relationship of the change in LVEF and the change in SUV in a cohort of patients with CS.
Methods 14 patients with CS were recruited. Fasting whole body and cardiac FDG-PET was performed. LV SUV (mean and maximum) was determined. LVEF was evaluated by gated N-13 ammonia or Rb-82 PET at baseline and follow-up. The changes of the LVEF classified into 3 categories; improved: absolute LVEF increased >/= 10%; no change: LVEF change < 10%; deteriorated: LVEF decreased >/=10%.
Results All 14 patients showed focal FDG uptake in the LV at baseline. 12 patients had AIT (treatment group) and 2 patients were observed without AIT. In the treatment group, the max SUVs in the LV after AIT were significantly decreased compared to those at the baseline (8.40+/-2.70 vs 3.40+/-1.65; p=0.0002) (similar degree of change for overall mean SUVs) but EF did not change (44.3+/-17.0 vs 41.9+/-13.8; p=0.72). 8 out of 12 (67%) showed more than 50% reduction in SUVs at follow-up period: 2 had increased LVEF and 1 had reduced EF and 5 had no change. In the remaining 4 patients in the treatment group with less reduction in SUVs, 3 patients no change in LVEF, 1 patient showed deterioration of LVEF. In the 2 patients without AIT, 1 patient demonstrated more than 50% reduction in SUVs with improvement of LVEF, 1 patient showed no reduction in SUVs with no change in LVEF. There was no significant relationship between the change in max SUVs and change in EF (r2=0.04;p=0.48).
Conclusions In this small cohort, while AIT was associated with a significant reduction of FDG SUV with 8/12 patients having more than 50% reduction, there was not a significant effect on change in LVEF. Also 1/2 patients without AIT had a more than 50% reduction in SUV. Larger prospective studies are warranted.