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Journal of Nuclear Medicine

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Meeting ReportMolecular Targeting Probes - Radioactive and Nonradioactive

Comparison of a new 18F renal tracer, Al18F-NODA-butyric acid, with 131I-OIH in normal rats

Malgorzata Lipowska, Dinesh Shetty, Jeffrey Klenc, Eugene Malveaux, Larry Williams, Jonathon Nye, Hyunsuk Shim and Andrew Taylor
Journal of Nuclear Medicine May 2013, 54 (supplement 2) 1208;
Malgorzata Lipowska
1Radiology and Imaging Sciences, Emory University, Atlanta, GA
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Dinesh Shetty
1Radiology and Imaging Sciences, Emory University, Atlanta, GA
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Jeffrey Klenc
1Radiology and Imaging Sciences, Emory University, Atlanta, GA
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Eugene Malveaux
1Radiology and Imaging Sciences, Emory University, Atlanta, GA
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Larry Williams
1Radiology and Imaging Sciences, Emory University, Atlanta, GA
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Jonathon Nye
1Radiology and Imaging Sciences, Emory University, Atlanta, GA
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Hyunsuk Shim
1Radiology and Imaging Sciences, Emory University, Atlanta, GA
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Andrew Taylor
1Radiology and Imaging Sciences, Emory University, Atlanta, GA
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Abstract

1208

Objectives Al18F-NODA-butyric acid complex was recently identified as a potential renal tracer (JNM 2011, 52, Suppl.1,170P). The goal of this work was to evaluate the pharmacokinetic properties of the 18F agent using dynamic microPET/CT and by comparison with those of 131I-OIH, the clinical radioactive standard for the measurement of effective renal plasma flow.

Methods Radiolabeling of the NODA-butyric acid (NODA-BA) ligand was performed using Al18F method; the labeled compound was isolated by HPLC. Biodistribution studies were performed in rats (n = 5) at 10 and 60 min post-injection, using 131I-OIH as an internal control. Urine, blood samples and vital organs were collected, counted and %ID/organ determined. Urine was also analyzed for metabolites by HPLC. Dynamic microPET/CT studies were conducted in rats.

Results An aqueous, one step Al18F labeling of NODA-BA produced the Al18F-NODA-BA complex with high radiochemical purity (> 98%). The labeled complex was stable at pH 7.4 for 5h at 25 °C. The percent injected dose in the urine at 10 and 60 min was 58 ± 4% and 92 ± 3% that of 131I-OIH, respectively. The hepatic/gastrointestinal activity was less for the 18F tracer than for the 131I tracer both at 10 and 60 min; however, Al18F-NODA-BA was better retained in blood at 10 min (8.5 ± 0.8%) than was 131I-OIH (5.1 ± 0.5%). The kidney activity was comparable at 10 min (~ 5 %) but was higher for Al18F-NODA-BA at 60 min (1.9 ± 0.4% for 18F tracer vs. 0.7 ± 0.4% for 131I tracer). The 18F tracer was excreted intact in the urine, with no metabolic products. Dynamic PET showed a rapid transit of the 18F tracer through the kidneys into the bladder.

Conclusions These encouraging results warrant further investigation of Al18F-based compounds as PET radiotracers for the evaluation of renal function.

Research Support NIH Grant R37 DK38842

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Journal of Nuclear Medicine
Vol. 54, Issue supplement 2
May 2013
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Comparison of a new 18F renal tracer, Al18F-NODA-butyric acid, with 131I-OIH in normal rats
Malgorzata Lipowska, Dinesh Shetty, Jeffrey Klenc, Eugene Malveaux, Larry Williams, Jonathon Nye, Hyunsuk Shim, Andrew Taylor
Journal of Nuclear Medicine May 2013, 54 (supplement 2) 1208;

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Comparison of a new 18F renal tracer, Al18F-NODA-butyric acid, with 131I-OIH in normal rats
Malgorzata Lipowska, Dinesh Shetty, Jeffrey Klenc, Eugene Malveaux, Larry Williams, Jonathon Nye, Hyunsuk Shim, Andrew Taylor
Journal of Nuclear Medicine May 2013, 54 (supplement 2) 1208;
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