PT - JOURNAL ARTICLE AU - Lipowska, Malgorzata AU - Shetty, Dinesh AU - Klenc, Jeffrey AU - Malveaux, Eugene AU - Williams, Larry AU - Nye, Jonathon AU - Shim, Hyunsuk AU - Taylor, Andrew TI - Comparison of a new <sup>18</sup>F renal tracer, Al<sup>18</sup>F-NODA-butyric acid, with <sup>131</sup>I-OIH in normal rats DP - 2013 May 01 TA - Journal of Nuclear Medicine PG - 1208--1208 VI - 54 IP - supplement 2 4099 - http://jnm.snmjournals.org/content/54/supplement_2/1208.short 4100 - http://jnm.snmjournals.org/content/54/supplement_2/1208.full SO - J Nucl Med2013 May 01; 54 AB - 1208 Objectives Al18F-NODA-butyric acid complex was recently identified as a potential renal tracer (JNM 2011, 52, Suppl.1,170P). The goal of this work was to evaluate the pharmacokinetic properties of the 18F agent using dynamic microPET/CT and by comparison with those of 131I-OIH, the clinical radioactive standard for the measurement of effective renal plasma flow. Methods Radiolabeling of the NODA-butyric acid (NODA-BA) ligand was performed using Al18F method; the labeled compound was isolated by HPLC. Biodistribution studies were performed in rats (n = 5) at 10 and 60 min post-injection, using 131I-OIH as an internal control. Urine, blood samples and vital organs were collected, counted and %ID/organ determined. Urine was also analyzed for metabolites by HPLC. Dynamic microPET/CT studies were conducted in rats. Results An aqueous, one step Al18F labeling of NODA-BA produced the Al18F-NODA-BA complex with high radiochemical purity (&gt; 98%). The labeled complex was stable at pH 7.4 for 5h at 25 °C. The percent injected dose in the urine at 10 and 60 min was 58 ± 4% and 92 ± 3% that of 131I-OIH, respectively. The hepatic/gastrointestinal activity was less for the 18F tracer than for the 131I tracer both at 10 and 60 min; however, Al18F-NODA-BA was better retained in blood at 10 min (8.5 ± 0.8%) than was 131I-OIH (5.1 ± 0.5%). The kidney activity was comparable at 10 min (~ 5 %) but was higher for Al18F-NODA-BA at 60 min (1.9 ± 0.4% for 18F tracer vs. 0.7 ± 0.4% for 131I tracer). The 18F tracer was excreted intact in the urine, with no metabolic products. Dynamic PET showed a rapid transit of the 18F tracer through the kidneys into the bladder. Conclusions These encouraging results warrant further investigation of Al18F-based compounds as PET radiotracers for the evaluation of renal function. Research Support NIH Grant R37 DK38842