Article Figures & Data
Figures
- FIGURE 1.
18F-FLT (A), 18F-FDG (B), and 18F-FMISO (C) images.
- FIGURE 2.
(A) Reproducibility of 18F-FMISO volume delineation for 1 patient (orange, good agreement; green, moderate agreement; blue, poor agreement). (B) Reproducibility of 18F-FLT volume delineation for 1 patient (orange, good agreement; green, moderate agreement; blue, poor agreement).
- FIGURE 3.
Data are mean ± SEM volumes (mL) for 22 methods of volume delineation for 18F-FMISO.
- FIGURE 4.
Data are mean ± SEM volumes (mL) for 22 methods of volume delineation for 18F-FLT.
Tables
- TABLE 1
Global κ-Test for Visual Analysis of PET/CT Images for 18 Nuclear Medicine Physicians at 18 Centers
κ 18F-FDG 18F-FMISO 18F-FLT 5 classes 0.59 0.43 0.44 2 classes 0.81 0.77 0.77 18F-FDG 18F-FMISO 18F-FLT κ Tumor Node Tumor Node Tumor Node 5 classes 0.84 0.51 0.45 0.44 0.49 0.41 2 classes 0.87 0.78 0.65 0.81 0.84 0.74 18F-FDG 18F-FMISO 18F-FLT κ Before radiochemotherapy During radiochemotherapy Before radiochemotherapy During radiochemotherapy Before radiochemotherapy During radiochemotherapy 5 classes 0.65 0.53 0.45 0.43 0.52 0.34 2 classes 0.88 0.73 0.74 0.80 0.79 0.73 18F-FMISO 18F-FLT Segmentation Sensitivity Specificity AUC Sensitivity Specificity AUC 1.2 1 0.56 0.78 0.92 0.5 0.71 1.4 0.86 0.72 0.79 0.92 0.83 0.88 SUVmax 40% 1 0 0.50 1 0 0.50 50% 1 0 0.50 1 0 0.50 SUVmaxAorta 1.3 × 1 0.56 0.78 0.96 0.5 0.73 1.5 × 0.71 0.96 0.84 0.92 0.83 0.88 1.6 × 0.14 1 0.57 0.92 0.83 0.88 SUVmeanAorta 1.3 × 1 0.36 0.68 1 0.33 0.67 1.5 × 1 0.4 0.70 1 0 0.50 1.6 × 1 0.56 0.78 1 0 0.50 SUVmaxLung 1.3 × 1 0 0.50 1 0 0.50 1.5 × 1 0.1 0.55 1 0.33 0.67 1.6 × 1 0.1 0.55 1 0.33 0.67 SUVmeanLung 1.3 × 1 0 0.50 1 0 0.50 1.5 × 1 0 0.50 1 0 0.50 1.6 × 1 0 0.50 1 0 0.50 SUVmaxMuscle 1.3 × 0.43 0.96 0.70 0.96 0.83 0.90 1.5 × 0.29 1 0.65 0.92 0.83 0.88 1.6 × 0.29 1 0.65 0.87 0.83 0.85 SUVmeanMuscle 1.3 × 0 0.96 0.48 1 0.17 0.59 1.5 × 1 0.14 0.57 1 0.17 0.59 1.6 × 1 0.52 0.76 0.96 0.17 0.57 For sensitivity and specificity reference standard defined by consensus group.
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