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Research ArticleBasic Science Investigations

A Pretargeted PET Imaging Strategy Based on Bioorthogonal Diels–Alder Click Chemistry

Brian M. Zeglis, Kuntal K. Sevak, Thomas Reiner, Priya Mohindra, Sean D. Carlin, Pat Zanzonico, Ralph Weissleder and Jason S. Lewis
Journal of Nuclear Medicine August 2013, 54 (8) 1389-1396; DOI: https://doi.org/10.2967/jnumed.112.115840
Brian M. Zeglis
1Department of Radiology, Memorial Sloan-Kettering Cancer Center, New York, New York
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Kuntal K. Sevak
1Department of Radiology, Memorial Sloan-Kettering Cancer Center, New York, New York
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Thomas Reiner
1Department of Radiology, Memorial Sloan-Kettering Cancer Center, New York, New York
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Priya Mohindra
1Department of Radiology, Memorial Sloan-Kettering Cancer Center, New York, New York
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Sean D. Carlin
1Department of Radiology, Memorial Sloan-Kettering Cancer Center, New York, New York
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Pat Zanzonico
2Department of Medical Physics, Memorial Sloan-Kettering Cancer Center, New York, New York; and
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Ralph Weissleder
3Center for Systems Biology, Massachusetts General Hospital, Boston, Massachusetts
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Jason S. Lewis
1Department of Radiology, Memorial Sloan-Kettering Cancer Center, New York, New York
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Journal of Nuclear Medicine: 54 (8)
Journal of Nuclear Medicine
Vol. 54, Issue 8
August 1, 2013
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A Pretargeted PET Imaging Strategy Based on Bioorthogonal Diels–Alder Click Chemistry
Brian M. Zeglis, Kuntal K. Sevak, Thomas Reiner, Priya Mohindra, Sean D. Carlin, Pat Zanzonico, Ralph Weissleder, Jason S. Lewis
Journal of Nuclear Medicine Aug 2013, 54 (8) 1389-1396; DOI: 10.2967/jnumed.112.115840

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A Pretargeted PET Imaging Strategy Based on Bioorthogonal Diels–Alder Click Chemistry
Brian M. Zeglis, Kuntal K. Sevak, Thomas Reiner, Priya Mohindra, Sean D. Carlin, Pat Zanzonico, Ralph Weissleder, Jason S. Lewis
Journal of Nuclear Medicine Aug 2013, 54 (8) 1389-1396; DOI: 10.2967/jnumed.112.115840
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  • Optimizing the Therapeutic Index of sdAb-Based Radiopharmaceuticals Using Pretargeting
  • Harnessing 64Cu/67Cu for a theranostic approach to pretargeted radioimmunotherapy
  • Leveraging Bioorthogonal Click Chemistry to Improve 225Ac-Radioimmunotherapy of Pancreatic Ductal Adenocarcinoma
  • CD38-bispecific antibody pretargeted radioimmunotherapy for multiple myeloma and other B-cell malignancies
  • Pretargeted Imaging and Therapy
  • Establishment of the In Vivo Efficacy of Pretargeted Radioimmunotherapy Utilizing Inverse Electron Demand Diels-Alder Click Chemistry
  • Comparative Analysis of Bispecific Antibody and Streptavidin-Targeted Radioimmunotherapy for B-cell Cancers
  • Pretargeted Immuno-PET of Pancreatic Cancer: Overcoming Circulating Antigen and Internalized Antibody to Reduce Radiation Doses
  • Noninvasive brain cancer imaging with a bispecific antibody fragment, generated via click chemistry
  • Advances in the treatment of hematologic malignancies using immunoconjugates
  • Diels-Alder Reaction for Tumor Pretargeting: In Vivo Chemistry Can Boost Tumor Radiation Dose Compared with Directly Labeled Antibody
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More in this TOC Section

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  • Counting Rate Characteristics and Image Distortion in Preclinical PET Imaging During Radiopharmaceutical Therapy
  • Design and Fabrication of Kidney Phantoms for Internal Radiation Dosimetry Using 3D Printing Technology
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Keywords

  • positron emission tomography (PET)
  • pretargeting
  • click chemistry
  • antibody
  • colorectal cancer
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