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Journal of Nuclear Medicine

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Research ArticleBasic Science Investigations

18F-EF5 PET Imaging as an Early Response Biomarker for the Hypoxia-Activated Prodrug SN30000 Combined with Radiation Treatment in a Non–Small Cell Lung Cancer Xenograft Model

Satish K. Chitneni, Gerald T. Bida, Hong Yuan, Gregory M. Palmer, Michael P. Hay, Thorsten Melcher, William R. Wilson, Michael R. Zalutsky and Mark W. Dewhirst
Journal of Nuclear Medicine August 2013, 54 (8) 1339-1346; DOI: https://doi.org/10.2967/jnumed.112.116293
Satish K. Chitneni
1Department of Radiology, Duke University Medical Center, Durham, North Carolina
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Gerald T. Bida
1Department of Radiology, Duke University Medical Center, Durham, North Carolina
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Hong Yuan
2Biomedical Research Imaging Center (BRIC), University of North Carolina, Chapel Hill, North Carolina
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Gregory M. Palmer
3Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina
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Michael P. Hay
4Auckland Cancer Society Research Centre, University of Auckland, Auckland, New Zealand; and
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Thorsten Melcher
5Varian Medical Systems, Palo Alto, California
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William R. Wilson
4Auckland Cancer Society Research Centre, University of Auckland, Auckland, New Zealand; and
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Michael R. Zalutsky
1Department of Radiology, Duke University Medical Center, Durham, North Carolina
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Mark W. Dewhirst
3Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina
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Journal of Nuclear Medicine: 54 (8)
Journal of Nuclear Medicine
Vol. 54, Issue 8
August 1, 2013
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18F-EF5 PET Imaging as an Early Response Biomarker for the Hypoxia-Activated Prodrug SN30000 Combined with Radiation Treatment in a Non–Small Cell Lung Cancer Xenograft Model
Satish K. Chitneni, Gerald T. Bida, Hong Yuan, Gregory M. Palmer, Michael P. Hay, Thorsten Melcher, William R. Wilson, Michael R. Zalutsky, Mark W. Dewhirst
Journal of Nuclear Medicine Aug 2013, 54 (8) 1339-1346; DOI: 10.2967/jnumed.112.116293

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18F-EF5 PET Imaging as an Early Response Biomarker for the Hypoxia-Activated Prodrug SN30000 Combined with Radiation Treatment in a Non–Small Cell Lung Cancer Xenograft Model
Satish K. Chitneni, Gerald T. Bida, Hong Yuan, Gregory M. Palmer, Michael P. Hay, Thorsten Melcher, William R. Wilson, Michael R. Zalutsky, Mark W. Dewhirst
Journal of Nuclear Medicine Aug 2013, 54 (8) 1339-1346; DOI: 10.2967/jnumed.112.116293
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Cited By...

  • PET/CT in the Evaluation of Hypoxia for Radiotherapy Planning in Head and Neck Tumors: Systematic Literature Review
  • Dual Targeting of Hypoxia and Homologous Recombination Repair Dysfunction in Triple-Negative Breast Cancer
  • Comparison of the Hypoxia PET Tracer 18F-EF5 to Immunohistochemical Marker EF5 in 3 Different Human Tumor Xenograft Models
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More in this TOC Section

  • Design and Fabrication of Kidney Phantoms for Internal Radiation Dosimetry Using 3D Printing Technology
  • Synthesis and Biologic Evaluation of Novel 18F-Labeled Probes Targeting Prostate-Specific Membrane Antigen for PET of Prostate Cancer
  • Tumor-Specific Binding of Radiolabeled PEGylated GIRLRG Peptide: A Novel Agent for Targeting Cancers
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Keywords

  • 18F-EF5
  • SN30000
  • prodrug
  • hypoxia
  • PET
  • response
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