11C-Acetate Clearance as an Index of Oxygen Consumption of the Right Myocardium in Idiopathic Pulmonary Arterial Hypertension: A Validation Study Using 15O-Labeled Tracers and PET

Yeun Ying Wong; Pieter Raijmakers; Jasmijn van Campen; Willem J. van der Laarse; Paul Knaapen; Mark Lubberink; Gerrina Ruiter; Anton Vonk Noordegraaf; Adriaan A. Lammertsma

doi:10.2967/jnumed.112.115915

Research ArticleClinical Investigations

¹¹C-Acetate Clearance as an Index of Oxygen Consumption of the Right Myocardium in Idiopathic Pulmonary Arterial Hypertension: A Validation Study Using ¹⁵O-Labeled Tracers and PET

Yeun Ying Wong, Pieter Raijmakers, Jasmijn van Campen, Willem J. van der Laarse, Paul Knaapen, Mark Lubberink, Gerrina Ruiter, Anton Vonk Noordegraaf and Adriaan A. Lammertsma

Journal of Nuclear Medicine August 2013, 54 (8) 1258-1262; DOI: https://doi.org/10.2967/jnumed.112.115915

Yeun Ying Wong

1Department of Pulmonology, VU University Medical Center, Amsterdam, The Netherlands

2Department of Physiology, VU University Medical Center, Amsterdam, The Netherlands

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Pieter Raijmakers

3Department of Nuclear Medicine and PET Research, VU University Medical Center, Amsterdam, The Netherlands; and

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Jasmijn van Campen

1Department of Pulmonology, VU University Medical Center, Amsterdam, The Netherlands

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Willem J. van der Laarse

2Department of Physiology, VU University Medical Center, Amsterdam, The Netherlands

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Paul Knaapen

4Department of Cardiology, Institute of Cardiovascular Research, VU University Medical Center, Amsterdam, The Netherlands

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Mark Lubberink

3Department of Nuclear Medicine and PET Research, VU University Medical Center, Amsterdam, The Netherlands; and

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Gerrina Ruiter

1Department of Pulmonology, VU University Medical Center, Amsterdam, The Netherlands

2Department of Physiology, VU University Medical Center, Amsterdam, The Netherlands

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Anton Vonk Noordegraaf

1Department of Pulmonology, VU University Medical Center, Amsterdam, The Netherlands

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Adriaan A. Lammertsma

3Department of Nuclear Medicine and PET Research, VU University Medical Center, Amsterdam, The Netherlands; and

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Journal of Nuclear Medicine

Vol. 54, Issue 8

August 1, 2013

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¹¹C-Acetate Clearance as an Index of Oxygen Consumption of the Right Myocardium in Idiopathic Pulmonary Arterial Hypertension: A Validation Study Using ¹⁵O-Labeled Tracers and PET

Yeun Ying Wong, Pieter Raijmakers, Jasmijn van Campen, Willem J. van der Laarse, Paul Knaapen, Mark Lubberink, Gerrina Ruiter, Anton Vonk Noordegraaf, Adriaan A. Lammertsma

Journal of Nuclear Medicine Aug 2013, 54 (8) 1258-1262; DOI: 10.2967/jnumed.112.115915

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¹¹C-Acetate Clearance as an Index of Oxygen Consumption of the Right Myocardium in Idiopathic Pulmonary Arterial Hypertension: A Validation Study Using ¹⁵O-Labeled Tracers and PET

Yeun Ying Wong, Pieter Raijmakers, Jasmijn van Campen, Willem J. van der Laarse, Paul Knaapen, Mark Lubberink, Gerrina Ruiter, Anton Vonk Noordegraaf, Adriaan A. Lammertsma

Journal of Nuclear Medicine Aug 2013, 54 (8) 1258-1262; DOI: 10.2967/jnumed.112.115915

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Keywords

11C-acetate
15O
PET
monoexponential curve fitting
pulmonary arterial hypertension
right ventricle
myocardial oxygen consumption
rate–pressure product

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¹¹C-Acetate Clearance as an Index of Oxygen Consumption of the Right Myocardium in Idiopathic Pulmonary Arterial Hypertension: A Validation Study Using ¹⁵O-Labeled Tracers and PET

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