Treatment of Triple-Negative Breast Cancer Using Anti-EGFR–Directed Radioimmunotherapy Combined with Radiosensitizing Chemotherapy and PARP Inhibitor

Fares Al-Ejeh; Wei Shi; Mariska Miranda; Peter T. Simpson; Ana Cristina Vargas; Sarah Song; Adrian P. Wiegmans; Alex Swarbrick; Alana L. Welm; Michael P. Brown; Georgia Chenevix-Trench; Sunil R. Lakhani; Kum Kum Khanna

doi:10.2967/jnumed.112.111534

Research ArticleBasic Science Investigations

Treatment of Triple-Negative Breast Cancer Using Anti-EGFR–Directed Radioimmunotherapy Combined with Radiosensitizing Chemotherapy and PARP Inhibitor

Fares Al-Ejeh, Wei Shi, Mariska Miranda, Peter T. Simpson, Ana Cristina Vargas, Sarah Song, Adrian P. Wiegmans, Alex Swarbrick, Alana L. Welm, Michael P. Brown, Georgia Chenevix-Trench, Sunil R. Lakhani and Kum Kum Khanna

Journal of Nuclear Medicine June 2013, 54 (6) 913-921; DOI: https://doi.org/10.2967/jnumed.112.111534

Fares Al-Ejeh

1Signal Transduction Laboratory, Queensland Institute of Medical Research, Brisbane, Queensland, Australia

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Wei Shi

1Signal Transduction Laboratory, Queensland Institute of Medical Research, Brisbane, Queensland, Australia

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Mariska Miranda

1Signal Transduction Laboratory, Queensland Institute of Medical Research, Brisbane, Queensland, Australia

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Peter T. Simpson

2UQ Centre for Clinical Research, University of Queensland, Brisbane, Queensland, Australia

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Ana Cristina Vargas

2UQ Centre for Clinical Research, University of Queensland, Brisbane, Queensland, Australia

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Sarah Song

2UQ Centre for Clinical Research, University of Queensland, Brisbane, Queensland, Australia

3Queensland Centre for Medical Genomics, Institute for Molecular Bioscience, University of Queensland, St. Lucia, Queensland, Australia

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Adrian P. Wiegmans

1Signal Transduction Laboratory, Queensland Institute of Medical Research, Brisbane, Queensland, Australia

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Alex Swarbrick

4St. Vincent’s Clinical School, Faculty of Medicine, University of New South Wales, Darlinghurst, New South Wales, Australia

5Cancer Research Program, Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia

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Alana L. Welm

6Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah

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Michael P. Brown

7Cancer Clinical Trials Unit, Royal Adelaide Hospital Cancer Centre, Adelaide, South Australia, Australia

8School of Medicine, University of Adelaide, Adelaide, South Australia, Australia

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Georgia Chenevix-Trench

9Cancer Genetics Laboratory, Queensland Institute of Medical Research, Brisbane, Queensland, Australia

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Sunil R. Lakhani

2UQ Centre for Clinical Research, University of Queensland, Brisbane, Queensland, Australia

10School of Medicine, University of Queensland, Brisbane, Queensland, Australia; and

11Pathology Queensland, Royal Brisbane and Women’s Hospital, Brisbane, Queensland, Australia

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Kum Kum Khanna

1Signal Transduction Laboratory, Queensland Institute of Medical Research, Brisbane, Queensland, Australia

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Journal of Nuclear Medicine

Vol. 54, Issue 6

June 1, 2013

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Treatment of Triple-Negative Breast Cancer Using Anti-EGFR–Directed Radioimmunotherapy Combined with Radiosensitizing Chemotherapy and PARP Inhibitor

Journal of Nuclear Medicine Jun 2013, 54 (6) 913-921; DOI: 10.2967/jnumed.112.111534

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Treatment of Triple-Negative Breast Cancer Using Anti-EGFR–Directed Radioimmunotherapy Combined with Radiosensitizing Chemotherapy and PARP Inhibitor

Journal of Nuclear Medicine Jun 2013, 54 (6) 913-921; DOI: 10.2967/jnumed.112.111534

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Keywords

triple-negative breast cancer
EGFR
PARP inhibitor
radioimmunotherapy
combination therapy

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