Research ArticleClinical Investigations

Attenuation Correction Maps for SPECT Myocardial Perfusion Imaging from Contrast-Enhanced Coronary CT Angiography: Gemstone Spectral Imaging with Single-Source Dual Energy and Material Decomposition

Tobias A. Fuchs, Bert-Ram Sah, Julia Stehli, Sacha Bull, Svetlana Dougoud, Martin W. Huellner, Oliver Gaemperli and Philipp A. Kaufmann
Journal of Nuclear Medicine December 2013, 54 (12) 2077-2080; DOI: https://doi.org/10.2967/jnumed.113.123570

Article Figures & Data

Figures

  • FIGURE 1.
    FIGURE 1.

    MPI polar plots with normal perfusion (A) and with partially reversible inferolateral perfusion defect (B). Findings with standard unenhanced CT AC (left) and virtual unenhanced CT AC (right) were identical.

  • FIGURE 2.
    FIGURE 2.

    Analysis of standard unenhanced CT (left) and virtual unenhanced CT (right) with soft-tissue (A), lung (B), and bone (C) windows revealed comparable HU in lung (ROI 1: −877 and −878, respectively), left ventricular (ROI 2: 41 and 46, respectively), and bone (ROI 3: 168 and 87, respectively) tissues.

  • FIGURE 3.
    FIGURE 3.

    Comparison of quantitative percent segmental tracer uptake with standard unenhanced CT AC and virtual unenhanced CT AC revealed excellent correlation coefficients at stress (low dose) (A) and at rest (high dose) (B) with narrow BA limits of agreement.

  • FIGURE 4.
    FIGURE 4.

    Hybrid cardiac SPECT/CCTA with standard unenhanced CT AC (A) and virtual unenhanced CT AC (B) revealed same perfusion defect in left anterior descending artery territory (pink).

Tables

  • TABLE 1

    Characteristics of 30 Patients

    CharacteristicValue
    Age (years, mean ± SD)66.1 ± 8.3
    Men18 (60)
    Body mass index (kg/m2, mean ± SD)24.7 ± 3.6
    Cardiovascular risk factors
     Hypertension16 (53)
     Dyslipidemia18 (60)
     Smoking14 (47)
     Positive family history12 (40)
     Diabetes2 (7)
    History of CAD
     Single-vessel CAD4 (13)
     Multivessel CAD7 (23)
     Myocardial infarction5 (17)
     Invasive coronary angiography8 (27)
     Percutaneous coronary intervention7 (23)
     Coronary artery bypass grafting1 (3)

    • Values are reported as number of patients followed by percentage in parentheses unless otherwise indicated.

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