PT  - JOURNAL ARTICLE
AU  - Fuchs, Tobias A.
AU  - Sah, Bert-Ram
AU  - Stehli, Julia
AU  - Bull, Sacha
AU  - Dougoud, Svetlana
AU  - Huellner, Martin W.
AU  - Gaemperli, Oliver
AU  - Kaufmann, Philipp A.
TI  - Attenuation Correction Maps for SPECT Myocardial Perfusion Imaging from Contrast-Enhanced Coronary CT Angiography: Gemstone Spectral Imaging with Single-Source Dual Energy and Material Decomposition
AID  - 10.2967/jnumed.113.123570
DP  - 2013 Dec 01
TA  - Journal of Nuclear Medicine
PG  - 2077--2080
VI  - 54
IP  - 12
4099  - http://jnm.snmjournals.org/content/54/12/2077.short
4100  - http://jnm.snmjournals.org/content/54/12/2077.full
SO  - J Nucl Med2013 Dec 01; 54
AB  - The aim of this study was to explore the feasibility of attenuation correction (AC) of myocardial perfusion imaging (MPI) with a virtual unenhanced cardiac CT scan synthesized from contrast-enhanced single-source dual-energy coronary CT angiography. Methods: Segmental myocardial percentage uptake values obtained with AC were analyzed by use of correlation analysis and Bland–Altman limits of agreement (20-segment model), and clinical agreement was evaluated in 30 patients. Results: The 2 methods showed an excellent correlation for segmental myocardial percentage uptake at stress (r = 0.93; P < 0.001; low dose) and at rest (r = 0.90; P < 0.001; high dose) with narrow Bland–Altman limits of agreement (−6.8% to 7.8% and −7.8% to 7.4%, respectively). The levels of clinical agreement of SPECT MPI corrected with standard versus virtual unenhanced CT AC were 99% per coronary territory and 97% per patient. Conclusion: Our results suggest that AC of SPECT MPI with a virtual unenhanced CT scan synthesized from contrast-enhanced coronary CT angiography is feasible and reliable.