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Research ArticleBasic Science Investigations

Diels–Alder Reaction for Tumor Pretargeting: In Vivo Chemistry Can Boost Tumor Radiation Dose Compared with Directly Labeled Antibody

Raffaella Rossin, Tilman Läppchen, Sandra M. van den Bosch, Richard Laforest and Marc S. Robillard
Journal of Nuclear Medicine November 2013, 54 (11) 1989-1995; DOI: https://doi.org/10.2967/jnumed.113.123745
Raffaella Rossin
1Department of Minimally Invasive Healthcare, Philips Research, Eindhoven, The Netherlands; and
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Tilman Läppchen
1Department of Minimally Invasive Healthcare, Philips Research, Eindhoven, The Netherlands; and
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Sandra M. van den Bosch
1Department of Minimally Invasive Healthcare, Philips Research, Eindhoven, The Netherlands; and
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Richard Laforest
2Division of Radiological Sciences, Washington University School of Medicine, St. Louis, Missouri
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Marc S. Robillard
1Department of Minimally Invasive Healthcare, Philips Research, Eindhoven, The Netherlands; and
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Journal of Nuclear Medicine: 54 (11)
Journal of Nuclear Medicine
Vol. 54, Issue 11
November 1, 2013
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Diels–Alder Reaction for Tumor Pretargeting: In Vivo Chemistry Can Boost Tumor Radiation Dose Compared with Directly Labeled Antibody
Raffaella Rossin, Tilman Läppchen, Sandra M. van den Bosch, Richard Laforest, Marc S. Robillard
Journal of Nuclear Medicine Nov 2013, 54 (11) 1989-1995; DOI: 10.2967/jnumed.113.123745

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Diels–Alder Reaction for Tumor Pretargeting: In Vivo Chemistry Can Boost Tumor Radiation Dose Compared with Directly Labeled Antibody
Raffaella Rossin, Tilman Läppchen, Sandra M. van den Bosch, Richard Laforest, Marc S. Robillard
Journal of Nuclear Medicine Nov 2013, 54 (11) 1989-1995; DOI: 10.2967/jnumed.113.123745
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Keywords

  • Diels-Alder
  • pretargeting
  • clearing agent
  • 177Lu
  • dosimetry
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