Article Figures & Data
Figures
- FIGURE 1.
Representative PET maximum-intensity-projection images with MTV represented by dashed line on coronal (A) and sagittal (B) images. Sagittal image demonstrates clearer separation between tumor and bladder.
- FIGURE 2.
MTV-T by T classification of American Joint Committee on Cancer (AJCC).
- FIGURE 3.
Kaplan–Meier analysis of PFS (A), EFS (B), and OS (C) by MTV-T. Patients were separated into 2 groups based on receiver-operating-characteristic analysis. Solid line = patients with MTV ≤ 26 mL; dotted line = patients with MTV > 26 mL; ○ = censored individuals.
Tables
Characteristic n Sex Female 24 Male 15 HIV-positive 4 (10) T class T1 6 (15) T2 20 (51) T3 10 (26) T4 3 (8) N class N0 27 (70) N1 6 (15) N2 4 (10) N3 2 (5) Chemotherapy MMC/5FU 34 Cisplatin-based 4 5FU alone 1 Median patient age was 58 y, and age range was 40–87 y. Data in parentheses are percentages.
OS PFS EFS Parameter HR P HR P HR P Age (per y) 1.06 0.17 1.02 0.48 1.03 0.28 Sex (female vs. male) 0.467 0.41 2.49 0.26 1.45 0.55 T stage (T3/T4 vs. T1/T2) 5.48 0.07 5.01 0.02 4.11 0.02 Nodal status (N-positive vs. N-negative) 1.74 0.55 1.51 0.56 1.48 0.52 HIV status (HIV-positive vs. HIV-negative) 1.92 0.56 0.881 0.91 0.662 0.69 MMC-based chemotherapy (yes vs. no) 0.092 0.02 0.67 0.71 0.38 0.22 Time between PET and treatment (d) 0.95 0.49 1.048 0.23 1.022 0.58 MTV-T (per cm3) 1.02 0.04 1.03 0.004 1.03 0.002 MTV-P 1.02 0.048 1.04 0.001 1.03 0.004 MTV-N 1.16 0.029 1.20 0.015 1.19 0.019 TGA (per cm3) 1.003 0.053 1.004 0.006 1.003 0.02 SUVmax (per unit) 1.00 0.99 0.990 0.85 1.003 0.95 SUVmax-P 1.00 0.98 0.99 0.84 1.00 0.96 SUVmax-N 1.08 0.33 1.08 0.23 1.06 0.23 SUVpeak (per unit) 0.954 0.60 1.04 0.35 1.03 0.47 SUVpeak-P 0.96 0.68 1.01 0.94 1.01 0.93 SUVpeak-N 1.08 0.40 1.10 0.18 1.07 0.27 SUVmean (per unit) 0.960 0.73 0.900 0.28 0.933 0.39 OS PFS EFS Parameter HR P HR P HR P MTV-T (per mL) 1.014 0.19 1.028 0.01 1.024 0.022 T class (T3/T4 vs. T1/T2) 4.13 0.16 3.73 0.07 3.33 0.052 MTV-T (per mL) 1.026 0.02 1.037 0.002 1.033 0.003 Age (per y) 1.079 0.10 1.039 0.23 1.042 0.13 MTV-T (per mL) 1.019 0.06 1.037 0.001 1.029 0.004 Gender (female vs. male) 0.561 0.55 3.437 0.19 1.438 0.57 MTV-T (per mL) 1.020 0.07 1.033 0.003 1.028 0.006 Nodal status (N-positive vs. N-negative) 1.086 0.93 0.995 1.0 1.183 0.80 MTV-T (per mL) 1.024 0.13 1.045 0.005 1.035 0.005 HIV status (HIV-positive vs. HIV-negative) 0.588 0.75 0.128 0.31 0.254 0.35 MTV-T (per mL) 1.028 0.02 1.034 0.002 1.031 0.003 MMC-based chemotherapy (yes vs. no) 0.054 0.01 0.474 0.50 0.293 0.13 MTV-T (per mL) 1.02 0.04 1.033 0.002 1.029 0.004 SUVmax 0.987 0.87 0.970 0.65 0.992 0.88 MTV-T (per mL) 1.023 0.03 1.032 0.002 1.028 0.005 SUVpeak 0.911 0.42 1.026 0.61 1.012 0.79 MTV-T (per mL) 1.020 0.04 1.033 0.001 1.028 0.004 SUVmean 0.953 0.72 0.874 0.26 0.926 0.39
