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Meeting ReportNeurosciences

Serotonin genotype and relations between daylight duration and brain 5-HTT binding

Esa Kauppila, Esko Vanninen, Salla Kaurijoki, Leila Karhunen, Kirsi Pietiläinen, Aila Rissanen, Jaakko Kaprio, Jari Tiihonen, Ullamari Pesonen and Jyrki Kuikka
Journal of Nuclear Medicine May 2012, 53 (supplement 1) 2014;
Esa Kauppila
1Department of Nuclear Medicine, North Karelia Central Hospital, Joensuu, Finland
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Esko Vanninen
2Department of Nuclear Medicine, University of Eastern Finland, Kuopio, Finland
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Salla Kaurijoki
3University of Eastern Finland, Kuopio, Finland
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Leila Karhunen
3University of Eastern Finland, Kuopio, Finland
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Kirsi Pietiläinen
4Helsinki University Central Hospital, Helsinki, Finland
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Aila Rissanen
4Helsinki University Central Hospital, Helsinki, Finland
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Jaakko Kaprio
5Helsinki University, Helsinki, Finland
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Jari Tiihonen
6University of Eastern Finland, Kuopio, Finland
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Ullamari Pesonen
7University of Turku, Turku, Finland
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Jyrki Kuikka
2Department of Nuclear Medicine, University of Eastern Finland, Kuopio, Finland
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Abstract

2014

Objectives Daylight duration (LIGHT) is related to weight, blood pressure (BP), mood and brain 5-HTT binding. The aim of this study was to evaluate the influence of serotonin transporter genotype polymorphism (5-HTTLPR) on this interaction.

Methods We studied forty healthy young adults (25 ± 2 yrs), including fifteen monozygotic twins, who were genotyped by 5-HTTLPR (sixteen l/l, fourteen s carriers). We used 123-I-nor-beta-CIT SPECT for the evaluation of 5-HTT functions in thalamus and midbrain. Subsequent relations and genotype influence on them were studied: LIGHT (hours on the imaging day), 5-HTT binding, hip/waist, BMI, heart rate and BP.

Results In forty subjects there was significant relation between LIGHT and midbrain binding (R = -0.31, < 0.01). Apart from thalamus binding other variables did not vary significantly between the two genotype groups (p < 0.007 for thalamus, Matt-Whitney test). In the l/l group there was statistically significant relation between midbrain 5-HTT binding and LIGHT (rS = -0.56, p < 0.05; n = 16). The exclucion of subjects with abnormal BMI (> 27 kg/m2) revealed a strong association between LIGHT and midbrain 5-HTT binding in the remaining l/l group (rS = -0.82, p < 0.002; n = 11). While there were no significant relations between LIGHT and 5-HTT brain binding in s carriers, LIGHT was significantly related to systolic BP (rS = -0.62, p< 0.05), and there was tendency towards relations between both diastolic BP and hip/waist and LIGHT.

Conclusions Our preliminary findings suggested that higher midbrain 5-HTT binding was associated with less daylight in the l/l group. In s carriers less daylight was associated with higher SBP, but LIGHT and brain 5-HTT binding were not related

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Journal of Nuclear Medicine
Vol. 53, Issue supplement 1
May 2012
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Serotonin genotype and relations between daylight duration and brain 5-HTT binding
Esa Kauppila, Esko Vanninen, Salla Kaurijoki, Leila Karhunen, Kirsi Pietiläinen, Aila Rissanen, Jaakko Kaprio, Jari Tiihonen, Ullamari Pesonen, Jyrki Kuikka
Journal of Nuclear Medicine May 2012, 53 (supplement 1) 2014;

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Serotonin genotype and relations between daylight duration and brain 5-HTT binding
Esa Kauppila, Esko Vanninen, Salla Kaurijoki, Leila Karhunen, Kirsi Pietiläinen, Aila Rissanen, Jaakko Kaprio, Jari Tiihonen, Ullamari Pesonen, Jyrki Kuikka
Journal of Nuclear Medicine May 2012, 53 (supplement 1) 2014;
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