Abstract
T18
Introduction: Purpose of this study is to evaluate whether Siemens’s SPECT/CT ( Symbia T6) with Low Energy High Resolution (LEHR) collimator and Flash3D reconstruction combined with computed tomography - attenuation correction (CT - AC) can be applied for brain perfusion 123I-IMP SPECT imaging for three-dimensional stereotactic surface projection (3D-SSP).
Methods: LSF phantom, Cerebral blood flow brain phantom with skull cover ( male bone, female bone, acrylic ), cold rods phantom with male bone cover, and six chambers phantom with male bone cover were used. The acquisition time was determined by the SPECT count, that would be the condition of using Siemens's LEHR with 6 mCi of 123I-IMP administration and counting equal to 30 minutes of collection. The rotation radius (14, 15, 16 cm ) were set and collected, respectively. Finally, the visual judgement by two independent nuclear medicine physicians, validity of spatial resolutions recovery, linearity of the radioactivity and SPECT value, and the gray-to-white matter count ratio were evaluated.
Results: Visual inspection of image determined image reconstruction with Gaussin filter 10mm should be used. The spatial resolutions were constant while change the rotation radius (14, 15, 16cm). There is a linear relation between SPECT values and activity concentration of phantom, and the gray-to-white matter count ratio were nearly same while using male bone cover, female bone cover, and acrylic cover.
Conclusions: Siemens's SPECT/CT ( Symbia T6) with LEHR collimator and Flash3D reconstruction combined with CT - AC can be adapted for 3D-SSP upon brain perfusion 123I-IMP SPECT imaging.
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