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Research ArticleFocus on Molecular Imaging

PET of Hypoxia: Current and Future Perspectives

Sean Carlin and John L. Humm
Journal of Nuclear Medicine August 2012, 53 (8) 1171-1174; DOI: https://doi.org/10.2967/jnumed.111.099770
Sean Carlin
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John L. Humm
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  • FIGURE 1.
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    FIGURE 1.

    (A) Histologic tumor section indicating hypoxia tracer pimonidazole (green) and vascular perfusion marker Hoechst 33342 (blue). (B) Same image with six 5-mm2 areas superimposed, representing approximate resolution of a clinical PET scanner. (C) Single 5-mm2 region at high magnification, containing approximately 20% pimonidazole-positive area. (D–F) Same pimonidazole distribution, but with a gaussian blur of 1 mm (E) and 5 mm (F) applied. This series demonstrates that PET voxel values are a function of both maximal uptake of tracer and hypoxic fraction of voxel. Averaging signal results in lowering overall tumor-to-blood ratios for hypoxia tracers. Increasing PET spatial resolution (E vs. F) would result in improved visualization of regions with higher tumor-to-blood ratios.

  • FIGURE 2.
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    FIGURE 2.

    Results of a dynamic PET scan as a function of time after injection with 18F-fluoromisonidazole. Single reconstructed PET slice is displayed through center of head and neck tumor. First 5 frames were of 1-min duration, followed by 5 frames of 5-min duration. At 30 min after injection, patient was removed from scanner and then reimaged at 90 min and 180 min after injection. Images were coregistered using low-dose CT scan (depicted in final image in series). This series shows evolution of 18F-fluoromisonidazole distribution within patient from initial blood pool to selective sequestration within hypoxic tumor subvolume.

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Journal of Nuclear Medicine: 53 (8)
Journal of Nuclear Medicine
Vol. 53, Issue 8
August 1, 2012
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PET of Hypoxia: Current and Future Perspectives
Sean Carlin, John L. Humm
Journal of Nuclear Medicine Aug 2012, 53 (8) 1171-1174; DOI: 10.2967/jnumed.111.099770

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PET of Hypoxia: Current and Future Perspectives
Sean Carlin, John L. Humm
Journal of Nuclear Medicine Aug 2012, 53 (8) 1171-1174; DOI: 10.2967/jnumed.111.099770
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  • Article
    • Abstract
    • ANALYSIS OF HYPOXIA PET IMAGES
    • DYNAMIC HYPOXIA PET
    • CURRENT CLINICAL HYPOXIA PET TRACERS
    • HYPOXIA PET TRACERS: THE NEXT GENERATION
    • CLINICAL APPLICATIONS OF HYPOXIA IMAGING
    • CONCLUSION
    • Acknowledgments
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  • Hypoxia and tissue destruction in pulmonary TB
  • Event-by-Event Continuous Respiratory Motion Correction for Dynamic PET Imaging
  • In Vivo Imaging of Hypoxia in Atherosclerotic Plaques in Humans
  • A Comparison of the Imaging Characteristics and Microregional Distribution of 4 Hypoxia PET Tracers
  • A Comparison of the Behavior of 64Cu-Acetate and 64Cu-ATSM In Vitro and In Vivo
  • Interobserver Agreement of Qualitative Analysis and Tumor Delineation of 18F-Fluoromisonidazole and 3'-Deoxy-3'-18F-Fluorothymidine PET Images in Lung Cancer
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