Article Figures & Data
Figures
- FIGURE 1.
(A) Histologic tumor section indicating hypoxia tracer pimonidazole (green) and vascular perfusion marker Hoechst 33342 (blue). (B) Same image with six 5-mm2 areas superimposed, representing approximate resolution of a clinical PET scanner. (C) Single 5-mm2 region at high magnification, containing approximately 20% pimonidazole-positive area. (D–F) Same pimonidazole distribution, but with a gaussian blur of 1 mm (E) and 5 mm (F) applied. This series demonstrates that PET voxel values are a function of both maximal uptake of tracer and hypoxic fraction of voxel. Averaging signal results in lowering overall tumor-to-blood ratios for hypoxia tracers. Increasing PET spatial resolution (E vs. F) would result in improved visualization of regions with higher tumor-to-blood ratios.
- FIGURE 2.
Results of a dynamic PET scan as a function of time after injection with 18F-fluoromisonidazole. Single reconstructed PET slice is displayed through center of head and neck tumor. First 5 frames were of 1-min duration, followed by 5 frames of 5-min duration. At 30 min after injection, patient was removed from scanner and then reimaged at 90 min and 180 min after injection. Images were coregistered using low-dose CT scan (depicted in final image in series). This series shows evolution of 18F-fluoromisonidazole distribution within patient from initial blood pool to selective sequestration within hypoxic tumor subvolume.
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