Article Figures & Data
Figures
- FIGURE 1.
In vitro binding of 18F-NOTA-ZHER2:2395 to SK-OV-3 and SUM149 cells. Cells were incubated with 18F-NOTA-ZHER2:2395 in presence of unlabeled NOTA-ZHER2:2395, which was preincubated for 15 min at room temperature without acetonitrile, at 90°C in 25% acetonitrile (MeCN), or in presence of trastuzumab. RT = room temperature.
- FIGURE 2.
Competitive binding curves of IC50 determination of 19F-, 69F-, and 115In-NOTA-ZHER2:2395 on SK-OV-3 cells. 111In-NOTA-ZHER2:2395 was used as radioactive tracer.
- FIGURE 3.
Biodistribution of 18F-NOTA-ZHER2:2395, 68Ga-NOTA-ZHER2:239, and 111In-NOTA-ZHER2:2395 in mice bearing subcutaneous SK-OV-3 xenografts at 1 h (A) and 4 h (B) after injection.
- FIGURE 4.
Tumor-to-blood ratios of 18F-NOTA-ZHER2:2395, 68Ga-NOTA-ZHER2:2395, and 111In-NOTA-ZHER2:2395 in mice bearing subcutaneous SK-OV-3 xenografts.
- FIGURE 5.
PET/CT and SPECT/CT images of mice bearing subcutaneous SK-OV-3 xenografts after injection of radiolabeled NOTA-ZHER2:2395.
Jump to section
Related Articles
Cited By...
- 18F-AlF-Labeled Biomolecule Conjugates as Imaging Pharmaceuticals
- In Vivo Imaging of the Programmed Death Ligand 1 by 18F PET
- Synthesis and Characterization of 18F-Interleukin-8 Using a Cell-Free Translation System and 4-18F-Fluoro-L-Proline
- Anti-miR182 Reduces Ovarian Cancer Burden, Invasion, and Metastasis: An In Vivo Study in Orthotopic Xenografts of Nude Mice
- Reply: Al18F Labeling of Affibody Molecules
- Al18F Labeling of Affibody Molecules
- First-in-Human Molecular Imaging of HER2 Expression in Breast Cancer Metastases Using the 111In-ABY-025 Affibody Molecule
- Improved Tumor Targeting of Anti-HER2 Nanobody Through N-Succinimidyl 4-Guanidinomethyl-3-Iodobenzoate Radiolabeling
- Three Methods for 18F Labeling of the HER2-Binding Affibody Molecule ZHER2:2891 Including Preclinical Assessment
- Synthesis, Preclinical Validation, Dosimetry, and Toxicity of 68Ga-NOTA-Anti-HER2 Nanobodies for iPET Imaging of HER2 Receptor Expression in Cancer