Abstract
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Objectives Myocardial perfusion imaging with MIBI has been worldwide utilized to assess coronary artery disease. Conventional SPECT (CSPECT) acquisition is incapable of measuring time activity curves (TAC) in myocardium (M) and blood-pool regions for quantifying myocardial blood flow with MIBI. This study demonstrates an imaging protocol utilizing a commercialized SPECT/CT system (Symbia T2) to perform multi-phases dynamic SPECT (DSPECT) acquisition and adaptive image recon that can characterize TAC.
Methods Five patients (male=4) who received clinically indicated same-day rest/dipyridamole-stress MIBI SPECT scan and showed normal myocardial perfusion were included in this study. Before the clinical CSPECT, DSPECT using a total of 20 forward-backward repeated phases (10×10sec+5×20sec+5×60sec) within 180 ° arc was immediately started for 10 sec prior to injecting MIBI (rest=8, stress=25 mCi). An attenuation correction CT was then acquired for 12 sec with low-dose radiation (0.95 mSv). DSPECT images were reconstructed with corrections for all physical factors and filtered with 10 mm Gaussian. Pixel values were converted to the unit of Bq/ml for SUV calculation using a conversion factor generated from the previous phantom study. Each TAC was analyzed to determine time points when peak SUV (pSUV) in left ventricle cavity (LVC) or M was reached at the dynamic phase, and when stabilized SUV (sSUV) was attained in both regions during the equilibrium phase.
Results In the table.
Conclusions Dynamic SPECT/CT protocol capable of dynamic acquisition and corrections for physical factors can be a useful imaging method to quantitatively measure time activity curves in myocardium and blood-pool regions that provide necessary components for the next step of myocardial blood flow quantitation
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