Abstract
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Objectives Our objective was to determine the efficacy of 18F-FDG PET/CT in restaging of previously operated colorectal cancer (CRC) patients whose tumor markers are elevated and/or findings of conventional imaging modalities (CIM) are suspicious, equivocal or pathological.
Methods Retrospective analysis of 75 patients (42 males, 33 females) with CRC with a mean age of 62.14 years (range between 30-82), who have been referred for 18F-FDG PET/CT evaluation, were performed
Results Recurrence were confirmed in 58 patients with the clinical follow-up or pathological findings after the PET/CT imaging. The sensitivity, specificity, accuracy, PPV and NPV of 18F-FDG PET/CT in the diagnosis of CRC recurrence were 93.1%, 88.2%, 92%, 96.4% and 78.9% respectively. 18F-FDG PET/CT was found to be superior to CIM and serum CEA measurements in the detection of recurrent disease in patients with CRC. 18F-FDG PET/CT was found to be efficient for early detection of recurred colorectal cancer patients with elevated serum CEA levels. Recurrence was detected by PET/CT imaging in 70.6% cases with elevated serum CEA levels and negative findings of CIM. In our study PET/CT has changed the management of the disease in 37.3% of the patients.
Conclusions In patients with CRC who had suspicious findings for recurrence, 18F-FDG PET/CT has changed the management with high sensitivity and specificity
Comparative results of PET/CT, CIM and serum CEA measurements on patient basis analysis
PPV, positive predictive value; NPV, negative predictive value; CIM, Conventional Imaging Methods
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