PT - JOURNAL ARTICLE AU - Uzun, Aysun AU - Özülker, Tamer AU - Özülker, Filiz AU - Özpacac, Tevfik TI - The efficacy of 18F-FDG PET/CT in the detection of recurrences in colorectal cancer DP - 2011 May 01 TA - Journal of Nuclear Medicine PG - 1827--1827 VI - 52 IP - supplement 1 4099 - http://jnm.snmjournals.org/content/52/supplement_1/1827.short 4100 - http://jnm.snmjournals.org/content/52/supplement_1/1827.full SO - J Nucl Med2011 May 01; 52 AB - 1827 Objectives Our objective was to determine the efficacy of 18F-FDG PET/CT in restaging of previously operated colorectal cancer (CRC) patients whose tumor markers are elevated and/or findings of conventional imaging modalities (CIM) are suspicious, equivocal or pathological. Methods Retrospective analysis of 75 patients (42 males, 33 females) with CRC with a mean age of 62.14 years (range between 30-82), who have been referred for 18F-FDG PET/CT evaluation, were performed Results Recurrence were confirmed in 58 patients with the clinical follow-up or pathological findings after the PET/CT imaging. The sensitivity, specificity, accuracy, PPV and NPV of 18F-FDG PET/CT in the diagnosis of CRC recurrence were 93.1%, 88.2%, 92%, 96.4% and 78.9% respectively. 18F-FDG PET/CT was found to be superior to CIM and serum CEA measurements in the detection of recurrent disease in patients with CRC. 18F-FDG PET/CT was found to be efficient for early detection of recurred colorectal cancer patients with elevated serum CEA levels. Recurrence was detected by PET/CT imaging in 70.6% cases with elevated serum CEA levels and negative findings of CIM. In our study PET/CT has changed the management of the disease in 37.3% of the patients. Conclusions In patients with CRC who had suspicious findings for recurrence, 18F-FDG PET/CT has changed the management with high sensitivity and specificityComparative results of PET/CT, CIM and serum CEA measurements on patient basis analysisPPV, positive predictive value; NPV, negative predictive value; CIM, Conventional Imaging Methods