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Journal of Nuclear Medicine

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Meeting ReportGeneral Clinical Specialties: Infectious Disease/Hematology

Correlation between bone marrow activity on F-18 FDG PET/CT and JAK2V617F mutation in myeloproliferative neoplasm

Sae-Ryung Kang, Ho-Chun Song, Jahae Kim, Su Woong Yoo, Jong-Ryool Oh, Byung-Hyun Byun, Hee-Seung Bom, Jung-Joon Min, Myung-Geun Shin and Yeo-Kyeoung Kim
Journal of Nuclear Medicine May 2011, 52 (supplement 1) 1369;
Sae-Ryung Kang
1Nuclear Medicine, Chonnam National University Hospital, Gwangju, Republic of Korea
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Ho-Chun Song
1Nuclear Medicine, Chonnam National University Hospital, Gwangju, Republic of Korea
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Jahae Kim
1Nuclear Medicine, Chonnam National University Hospital, Gwangju, Republic of Korea
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Su Woong Yoo
2Nuclear Medicine, Chonnam National University Hwasun Hospital, Hwasun, Republic of Korea
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Jong-Ryool Oh
1Nuclear Medicine, Chonnam National University Hospital, Gwangju, Republic of Korea
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Byung-Hyun Byun
2Nuclear Medicine, Chonnam National University Hwasun Hospital, Hwasun, Republic of Korea
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Hee-Seung Bom
2Nuclear Medicine, Chonnam National University Hwasun Hospital, Hwasun, Republic of Korea
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Jung-Joon Min
2Nuclear Medicine, Chonnam National University Hwasun Hospital, Hwasun, Republic of Korea
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Myung-Geun Shin
3Laboratory Medicine, Chonnam National University Hwasun Hospital, Hwasun, Republic of Korea
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Yeo-Kyeoung Kim
4Hematology, Chonnam National University Hwasun Hospital, Hwasun, Republic of Korea
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Abstract

1369

Objectives JAK2V617F (JAK2) mutation, a change of valine to phenylalanine at the 617 position of Janus kinase 2, is known to show an inherent tendency for poor prognosis in myeloproliferative neoplasms (MPNs). The objective of this study was to investigate the relationship between F-18 FDG bone marrow uptake and JAK2 mutation in patients with MPNs.

Methods Sixteen patients (mean age: 57y, range: 32-79y) diagnosed with MPNs from May 2007 to July 2010 were enrolled; 7 essential thrombocythemia (ET), 5 hypereosinophilic syndrome (HES), 2 primary myelofibrosis (PMF), 1 polycythemia vera (PV), and 1 unclassifiable MPN (MPN-u). All patients underwent FDG PET/CT, hematologic tests, and bone marrow biopsy. FDG uptake was semi-quantitatively assessed using mean standardized uptake values (SUV) in the lower thoracic and lumbar vertebrae, spleen and liver. Differences in bone marrow to liver uptake ratio (SUVBM/L), spleen to liver uptake ratio (SUVSp/L), and hematologic parameters according to the presence of JAK2 mutation were evaluated using Mann-Whitney U test.

Results JAK2 mutation was positive in 7 patients and negative in 9 patients. Among age, sex, SUVBM/L, SUVSp/L, and hematological parameters, only SUVBM/L and neutroplil count (x103/mm3) were significantly higher in patients with JAK2 mutation; 1.22±0.15 vs. 0.70±0.14 in SUVBM/L (p<0.001), 8.0±4.0 vs. 3.6±1.9 in neutrophil count (p=0.013). SUVBM/L over 0.9 could precisely predict the presence of JAK2 mutation (sensitivity: 100%, specificity: 100%, area under ROC curve: 1.000), followed by neutrophil count (sensitivity: 71%, specificity: 100%, area under ROC curve: 0.873).

Conclusions In MPNs, JAK2 mutation strongly correlated with bone marrow FDG activity. F-18 FDG PET can be used for a non-invasive imaging modality to predict prognosis in patients with MPNs

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Journal of Nuclear Medicine
Vol. 52, Issue supplement 1
May 2011
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Correlation between bone marrow activity on F-18 FDG PET/CT and JAK2V617F mutation in myeloproliferative neoplasm
Sae-Ryung Kang, Ho-Chun Song, Jahae Kim, Su Woong Yoo, Jong-Ryool Oh, Byung-Hyun Byun, Hee-Seung Bom, Jung-Joon Min, Myung-Geun Shin, Yeo-Kyeoung Kim
Journal of Nuclear Medicine May 2011, 52 (supplement 1) 1369;

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Correlation between bone marrow activity on F-18 FDG PET/CT and JAK2V617F mutation in myeloproliferative neoplasm
Sae-Ryung Kang, Ho-Chun Song, Jahae Kim, Su Woong Yoo, Jong-Ryool Oh, Byung-Hyun Byun, Hee-Seung Bom, Jung-Joon Min, Myung-Geun Shin, Yeo-Kyeoung Kim
Journal of Nuclear Medicine May 2011, 52 (supplement 1) 1369;
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