A study of the use of ⁶⁴Cu-AMD3465 as a PET imaging agent has shown it capable of detecting lesions in a CXCR4-dependent fashion with high tumor-to-muscle ratios. In the PET/CT images shown here, CXCR4 expression in subcutaneous U87 brain tumor xenografts is seen. This positron-emitting monocyclam analog may serve as a suitable scaffold for the synthesis of clinically translatable imaging agents.
See page 986.