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OtherBASIC SCIENCE INVESTIGATIONS

Changes in Radiation Dose with Variations in Human Anatomy: Larger and Smaller Normal-Stature Adults

Patrick M. Marine, Michael G. Stabin, Michael J. Fernald and Aaron B. Brill
Journal of Nuclear Medicine May 2010, 51 (5) 806-811; DOI: https://doi.org/10.2967/jnumed.109.073007
Patrick M. Marine
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Michael G. Stabin
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Michael J. Fernald
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Aaron B. Brill
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  • Article
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Figures

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  • FIGURE 1. 
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    FIGURE 1. 

    Comparison of traditional stylized (A) and realistic human body (B) models used in dose assessment.

  • FIGURE 2. 
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    FIGURE 2. 

    Selected organ masses, adult male models.

  • FIGURE 3. 
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    FIGURE 3. 

    Selected organ masses, adult female models.

  • FIGURE 4. 
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    FIGURE 4. 

    Selected SAF plots, adult male.

  • FIGURE 5. 
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    FIGURE 5. 

    Selected SAF plots, adult female.

Tables

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    TABLE 1

    Selected Organ Masses (g) for Adult Male Models

    Organ10th percentile25th percentile50th ICRP reference75th percentile90th percentile
    Adrenals11.8812.651414.9315.94
    Brain1,2911,4051,4501,4931,527
    Esophagus36.1739.294043.2646.52
    Eyes13.614.821515.1616.82
    Gallbladder62.5468.136871.6579.82
    Stomach341370.8400419.1443.7
    Small intestine595648.7650682.3779.4
    Right colon141154150170186
    Left colon133146150159174
    Rectosigmoid61.566.347075.1381.78
    Heart740804.5840833978.3
    Kidneys278.4302.7310322.5366.4
    Liver1,4891,6211,8001,9772,206
    Lungs1,0681,1621,2001,3441,502
    Pancreas127.5138.2140144161
    Prostate14.9416.32171819.49
    Salivary glands76.7682.638588.1192.22
    Skeleton8,2898,99010,50010,78111,800
    Spleen112.3121.5150172196.1
    Testes30.5633.163537.2839.73
    Thymus21.6823.32526.5327.76
    Thyroid18.4219.992020.5421.04
    Urinary bladder45.0548.635053.7259.02
    Total body63,56069,17073,00076,79091,720
    • View popup
    TABLE 2

    Selected Organ Masses (g) for Adult Female Models

    Organ10th percentile25th percentile50th percentile75th percentile90th percentile
    Adrenals11.5712.511313.715.33
    Brain1,1501,2431,3001,3171,361
    Esophagus32.4134.73537.7540.78
    Eyes14.1115.371515.7616.7
    Gallbladder50.3254.635661.6667.73
    Stomach336.6363.1370400.2438.4
    Small intestine570.9615.9600671.8737.6
    Right colon133142145151164
    Left colon136145145154174
    Rectosigmoid63.769.167076.2584.52
    Heart546.9588.8620628.6686.4
    Kidneys229.1246.7276306.8334.7
    Liver1,1501,2381,4001,5561,703
    Lungs816.28809501,0111,106
    Ovaries7.748.121111.4512.63
    Pancreas103.3110.6120138.6148.4
    Salivary glands65.2769.97074.978.24
    Skeleton5,8496,2847,8007,4708,240
    Spleen108.2116.4130152.5165.6
    Thymus17.3718.742020.8322.56
    Thyroid16.2717.491717.5918.21
    Urinary bladder36.0339.54044.548.03
    Uterus70.0575.38088.0395.35
    Total body50,68054,62060,00065,34071,420
    • View popup
    TABLE 3

    Organ Density Values Used in Anthropomorphic Models

    OrganDensity (g·cm−3)
    Adrenals1.02
    Salivary glands1.045
    Esophagus1.045
    Stomach1.045
    Small intestine1.045
    Large intestine1.045
    Rectosigmoid1.045
    Liver1.045
    Gallbladder1.045
    Pancreas1.045
    Brain1.04
    Heart1.03
    Eyes1.026
    Lungs0.30
    Skeleton1.3
    Spleen1.06
    Thymus1.025
    Thyroid1.05
    Kidneys1.05
    Bladder1.03
    Testes1.04
    Prostate1.03
    Ovaries1.05
    Uterus1.05
    • View popup
    TABLE 4

    Percentage Difference in SAFs per Kilogram Difference in Total Body Mass from 10th to 90th Percentile Phantoms, Adult Male

    OrganKidneysLiverLungsPancreasHeartSpleen
    Kidneys0.590.850.340.630.440.75
    Liver1.010.890.911.090.621.02
    Lungs0.460.740.690.520.620.21
    Pancreas0.471.080.650.520.390.72
    Heart0.400.450.660.510.620.39
    Spleen0.620.720.310.700.511.09
    • View popup
    TABLE 5

    Absolute Percentage Difference in SAFs from 10th to 90th Percentile Phantoms, Adult Male

    OrganKidneysLiverLungsPancreasHeartSpleen
    Kidneys17.725.410.218.913.122.6
    Liver30.426.727.432.818.630.7
    Lungs13.722.220.615.618.66.4
    Pancreas14.032.319.415.511.621.5
    Heart12.113.619.815.418.711.7
    Spleen18.721.79.321.115.432.6
    • View popup
    TABLE 6

    Percentage Difference in SAFs per Kilogram Difference in Total Body Mass from 10th to 90th Percentile Phantoms, Adult Female

    OrganKidneysLiverLungsPancreasHeartSpleen
    Kidneys0.770.580.370.570.470.50
    Liver0.560.860.610.680.260.74
    Lungs0.290.580.620.510.600.45
    Pancreas0.440.630.420.760.350.48
    Heart0.260.320.620.340.520.40
    Spleen0.500.640.480.510.360.87
    • View popup
    TABLE 7

    Absolute Percentage Difference in SAFs from 10th to 90th Percentile Phantoms, Adult Female

    OrganKidneysLiverLungsPancreasHeartSpleen
    Kidneys23.017.311.017.014.214.9
    Liver16.825.818.320.57.922.1
    Lungs8.817.418.715.217.913.4
    Pancreas13.218.812.722.910.414.4
    Heart7.89.718.510.215.512.1
    Spleen15.119.214.315.210.726.0
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Journal of Nuclear Medicine: 51 (5)
Journal of Nuclear Medicine
Vol. 51, Issue 5
May 2010
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Changes in Radiation Dose with Variations in Human Anatomy: Larger and Smaller Normal-Stature Adults
Patrick M. Marine, Michael G. Stabin, Michael J. Fernald, Aaron B. Brill
Journal of Nuclear Medicine May 2010, 51 (5) 806-811; DOI: 10.2967/jnumed.109.073007

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Changes in Radiation Dose with Variations in Human Anatomy: Larger and Smaller Normal-Stature Adults
Patrick M. Marine, Michael G. Stabin, Michael J. Fernald, Aaron B. Brill
Journal of Nuclear Medicine May 2010, 51 (5) 806-811; DOI: 10.2967/jnumed.109.073007
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