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OtherBASIC SCIENCE INVESTIGATIONS

Influence of Vitamin C on Salivary Absorbed Dose of 131I in Thyroid Cancer Patients: A Prospective, Randomized, Single-Blind, Controlled Trial

Bin Liu, Anren Kuang, Rui Huang, Zhen Zhao, Yu Zeng, Jiantao Wang and Rong Tian
Journal of Nuclear Medicine April 2010, 51 (4) 618-623; DOI: https://doi.org/10.2967/jnumed.109.071449
Bin Liu
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Anren Kuang
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Rui Huang
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Zhen Zhao
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Yu Zeng
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Jiantao Wang
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Rong Tian
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  • FIGURE 1. 
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    FIGURE 1. 

    Timing of start of vitamin C stimulation for each group. Ingestion of 131I was almost always at 5 pm for all patients. Groups A and B began sucking vitamin C at 6 pm and 10 pm, respectively, on day of 131I ingestion. Groups C and D began sucking vitamin C at 6 am and 6 pm, respectively, on second day of 131I ingestion. Because of nocturnal rest, no patients sucked vitamin C from 2 am to 6 am.

  • FIGURE 2. 
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    FIGURE 2. 

    In 49-y-old woman with differentiated papillary thyroid cancer, salivary time–activity curves after ingestion of 3.7 GBq of 131I for ablating postsurgical thyroid remnant. LP = left parotid; LSG = left submandibular gland; RP = right parotid; RSG = right submandibular gland.

  • FIGURE 3. 
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    FIGURE 3. 

    Box plot of absorbed dose (average of left and right glands) to parotid and submandibular salivary glands in 4 groups. Errors bars are 10th and 90th percentiles, gray box itself is boundary of 25th and 75th percentiles, and solid line indicates median.

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    TABLE 1

    Patient Characteristics

    Group
    CharacteristicABCD
    Start of vitamin C stimulation*1 h5 h13 h25 h
    Patients available (n)18181917
    Age (y)44 ± 1442 ± 1443 ± 1339 ± 12
    Sex (n, M/F)2/163/157/122/15
    Papillary/follicular (n)17/115/318/117/0
    Thyroid-stimulating hormone† (mU/L)85.2 ± 15.291.0 ± 16.386.9 ± 12.283.2 ± 13.5
    • ↵* After 131I ingestion.

    • ↵† Normal range = 0.27–4.2 mU/L.

    • For all comparisons, P > 0.05.

    • View popup
    TABLE 2

    Salivary Cumulated Activities in First 24 Hours, Divided by Total Cumulated Activities

    Group
    Salivary glandABCDP
    Parotid0.82 ± 0.070.87 ± 0.050.85 ± 0.120.88 ± 0.100.21
    Submandibular0.83 ± 0.090.80 ± 0.050.96 ± 0.090.94 ± 0.080.16
    • Data are mean ± SD.

    • View popup
    TABLE 3

    Salivary Dosimetry During First 24 Hours

    Group
    Salivary glandABCDP
    Parotid0.15 ± 0.060.14 ± 0.070.12 ± 0.080.14 ± 0.110.32
    Submandibular0.16 ± 0.040.14 ± 0.040.16 ± 0.070.16 ± 0.060.24
    • Data are mean mGy/MBq ± SD.

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Journal of Nuclear Medicine: 51 (4)
Journal of Nuclear Medicine
Vol. 51, Issue 4
April 2010
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Influence of Vitamin C on Salivary Absorbed Dose of 131I in Thyroid Cancer Patients: A Prospective, Randomized, Single-Blind, Controlled Trial
Bin Liu, Anren Kuang, Rui Huang, Zhen Zhao, Yu Zeng, Jiantao Wang, Rong Tian
Journal of Nuclear Medicine Apr 2010, 51 (4) 618-623; DOI: 10.2967/jnumed.109.071449

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Influence of Vitamin C on Salivary Absorbed Dose of 131I in Thyroid Cancer Patients: A Prospective, Randomized, Single-Blind, Controlled Trial
Bin Liu, Anren Kuang, Rui Huang, Zhen Zhao, Yu Zeng, Jiantao Wang, Rong Tian
Journal of Nuclear Medicine Apr 2010, 51 (4) 618-623; DOI: 10.2967/jnumed.109.071449
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