Skip to main content

Main menu

  • Home
  • Content
    • Current
    • Ahead of print
    • Past Issues
    • JNM Supplement
    • SNMMI Annual Meeting Abstracts
    • Continuing Education
    • JNM Podcasts
  • Subscriptions
    • Subscribers
    • Institutional and Non-member
    • Rates
    • Journal Claims
    • Corporate & Special Sales
  • Authors
    • Submit to JNM
    • Information for Authors
    • Assignment of Copyright
    • AQARA requirements
  • Info
    • Reviewers
    • Permissions
    • Advertisers
  • About
    • About Us
    • Editorial Board
    • Contact Information
  • More
    • Alerts
    • Feedback
    • Help
    • SNMMI Journals
  • SNMMI
    • JNM
    • JNMT
    • SNMMI Journals
    • SNMMI

User menu

  • Subscribe
  • My alerts
  • Log in
  • My Cart

Search

  • Advanced search
Journal of Nuclear Medicine
  • SNMMI
    • JNM
    • JNMT
    • SNMMI Journals
    • SNMMI
  • Subscribe
  • My alerts
  • Log in
  • My Cart
Journal of Nuclear Medicine

Advanced Search

  • Home
  • Content
    • Current
    • Ahead of print
    • Past Issues
    • JNM Supplement
    • SNMMI Annual Meeting Abstracts
    • Continuing Education
    • JNM Podcasts
  • Subscriptions
    • Subscribers
    • Institutional and Non-member
    • Rates
    • Journal Claims
    • Corporate & Special Sales
  • Authors
    • Submit to JNM
    • Information for Authors
    • Assignment of Copyright
    • AQARA requirements
  • Info
    • Reviewers
    • Permissions
    • Advertisers
  • About
    • About Us
    • Editorial Board
    • Contact Information
  • More
    • Alerts
    • Feedback
    • Help
    • SNMMI Journals
  • View or Listen to JNM Podcast
  • Visit JNM on Facebook
  • Join JNM on LinkedIn
  • Follow JNM on Twitter
  • Subscribe to our RSS feeds
Research ArticleBasic Science Investigation

90Y Bremsstrahlung Imaging for Absorbed-Dose Assessment in High-Dose Radioimmunotherapy

David Minarik, Katarina Sjögreen-Gleisner, Ola Linden, Karin Wingårdh, Jan Tennvall, Sven-Erik Strand and Michael Ljungberg
Journal of Nuclear Medicine December 2010, 51 (12) 1974-1978; DOI: https://doi.org/10.2967/jnumed.110.079897
David Minarik
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Katarina Sjögreen-Gleisner
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Ola Linden
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Karin Wingårdh
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jan Tennvall
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Sven-Erik Strand
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Michael Ljungberg
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • Info & Metrics
  • PDF
Loading

Article Figures & Data

Figures

  • Tables
  • FIGURE 1.
    • Download figure
    • Open in new tab
    • Download powerpoint
    FIGURE 1.

    Mean activity concentration in liver, spleen, kidneys, and lungs calculated from SPECT for patient 1. Act. conc. = activity concentration.

  • FIGURE 2.
    • Download figure
    • Open in new tab
    • Download powerpoint
    FIGURE 2.

    111In and 90Y images from patient 1 at first time point.

  • FIGURE 3.
    • Download figure
    • Open in new tab
    • Download powerpoint
    FIGURE 3.

    Unprocessed (A) and processed (B) 90Y WB images and corresponding unprocessed (C) and processed (D) 111In images. Curvature comes from registration process. ROIs used are shown in D.

Tables

  • Figures
    • View popup
    TABLE 1.

    Absorbed Doses to Organs, Calculated from SPECT Images

    Patient 1Patient 2Patient 3
    Organ90Y111ln%90Y111ln%90Y111ln%
    Liver12.112.10.014.711.824.610.811.0−1.8
    Spleen7.59.3−19.415.013.114.55.84.528.9
    Left kidney4.64.112.28.78.08.72.83.1−9.7
    Right kidney5.04.413.68.48.22.43.33.16.5
    Left lung10.56.464.113.511.121.69.15.662.5
    Right lung8.14.965.312.29.134.17.84.862.5
    • Corresponding 90Y-absorbed doses were calculated from 111In images using Equation 1. Percentages were calculated by (90Y − 111In)/111In × 100%.

    • View popup
    TABLE 2.

    Organ Activities at 1 Hour After injection, Calculated from WB Images

    Patient 1Patient 2Patient 3
    Organ90Y111ln%90Y111ln%90Y111ln%
    Total body3,1802,831125,2434,755101,9791,68917
    Liver243.5220.010.7488.1451.68.1221.9243.3−8.8
    Spleen25.826.2−1.6140.2187.2−25.163.859.18.0
    Left kidney36.138.7−6.776.182.7−8.031.627.415.3
    Right kidney26.430.5−13.557.855.93.524.725.00.0
    Left lung87.691.4−4.1135.6173.4−21.840.554.0−24.9
    Right lung94.5106.5−11.2173.5195.9−11.441.955.7−24.7
    • Corresponding 90Y activity was calculated from 111In images using Equation 2. Percentages were calculated by (90Y − 111In)/111In × 100%.

PreviousNext
Back to top

In this issue

Journal of Nuclear Medicine: 51 (12)
Journal of Nuclear Medicine
Vol. 51, Issue 12
December 1, 2010
  • Table of Contents
  • Table of Contents (PDF)
  • About the Cover
  • Index by author
Print
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for your interest in spreading the word on Journal of Nuclear Medicine.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
90Y Bremsstrahlung Imaging for Absorbed-Dose Assessment in High-Dose Radioimmunotherapy
(Your Name) has sent you a message from Journal of Nuclear Medicine
(Your Name) thought you would like to see the Journal of Nuclear Medicine web site.
Citation Tools
90Y Bremsstrahlung Imaging for Absorbed-Dose Assessment in High-Dose Radioimmunotherapy
David Minarik, Katarina Sjögreen-Gleisner, Ola Linden, Karin Wingårdh, Jan Tennvall, Sven-Erik Strand, Michael Ljungberg
Journal of Nuclear Medicine Dec 2010, 51 (12) 1974-1978; DOI: 10.2967/jnumed.110.079897

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Share
90Y Bremsstrahlung Imaging for Absorbed-Dose Assessment in High-Dose Radioimmunotherapy
David Minarik, Katarina Sjögreen-Gleisner, Ola Linden, Karin Wingårdh, Jan Tennvall, Sven-Erik Strand, Michael Ljungberg
Journal of Nuclear Medicine Dec 2010, 51 (12) 1974-1978; DOI: 10.2967/jnumed.110.079897
Twitter logo Facebook logo LinkedIn logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One
Bookmark this article

Jump to section

  • Article
    • Abstract
    • MATERIALS AND METHODS
    • RESULTS
    • DISCUSSION
    • CONCLUSION
    • Acknowledgments
    • REFERENCES
  • Figures & Data
  • Info & Metrics
  • PDF

Related Articles

  • No related articles found.
  • PubMed
  • Google Scholar

Cited By...

  • Cerenkov Luminescence Imaging for Radiation Dose Calculation of a 90Y-Labeled Gastrin-Releasing Peptide Receptor Antagonist
  • MIRD Pamphlet No. 23: Quantitative SPECT for Patient-Specific 3-Dimensional Dosimetry in Internal Radionuclide Therapy
  • Google Scholar

More in this TOC Section

  • Establishing In Vitro Dosimetric Models and Dose–Effect Relationships for 177Lu-DOTATATE in Neuroendocrine Tumors
  • Designed Ankyrin Repeat Protein–Mediated Peptide Nucleic Acid–Based Pretargeting: A Proof-of-Principle Study
  • [11C]ZTP-1: An Effective Short-Lived Radioligand for PET of Rat and Monkey Brain Phosphodiesterase Type 4 Subtype B
Show more Basic Science Investigation

Similar Articles

SNMMI

© 2025 SNMMI

Powered by HighWire