Article Figures & Data
Figures
- FIGURE 1.
68Ga-DOTANOC PET/CT (A) and HRCT (B) transaxial images of IPF patient. Areas of increased tracer uptake are peripheral and subpleural and correspond to areas of fibrotic abnormalities on HRCT.
- FIGURE 2.
68Ga-DOTANOC PET/CT MIP images of healthy control (A), NSIP patient (B), and IPF patient (C). 68Ga-DOTANOC uptake is evident only in IPF, showing typical peripheral distribution. Only faint uptake is present in NSIP, and no uptake is evident in healthy lungs.
- FIGURE 3.
Linear correlation (P = 0.002, R = 0.93) between 68Ga-DOTANOC PET/CT SUVmax and disease extent automatically assessed on HRCT.
Tables
IPF NSIP Mean Median SD Mean Median SD P PaO2 65.6 59.0 19.9 75.4 71.0 13.9 0.400 FVC 2.3 2.3 1.0 1.7 1.6 0.3 0.030 FVC% 63.9 64.0 21.9 73.7 65.0 17.5 0.460 FEV1 1.8 2.0 0.7 1.4 1.4 0.2 0.007 FEV1% 67.6 75.0 18.1 78.3 70.0 20.7 0.690 FEV1/FVC% 83.5 83.5 9.4 84.9 87.0 6.4 0.440 TLC 3.4 3.7 1.2 2.6 2.5 0.3 0.007 TLC% 52.8 59.0 17.1 63.4 64.0 7.4 0.015 RV 1.0 0.8 0.5 1.1 0.8 0.3 0.630 RV% 44.6 36.0 23.5 46.8 46.0 3.0 0.002 FEF25–75 2.9 2.4 1.5 1.9 1.8 0.5 0.012 FEF25%–75% 98.8 80.0 52.2 67.7 66.0 21.0 0.017 DLCO 9.4 9.2 4.2 7.5 10.9 5.6 0.140 DLCO% 31.3 25.0 13.6 38.4 48.0 29.5 0.010 PaO2 = arterial oxygen partial pressure; FVC = forced vital capacity; FEV1 = forced expiratory volume in 1 s; TLC = total lung capacity; RV = residual volume; FEF = forced expiratory flow; DLCO = carbon monoxide diffusing capacity.
Supplemental Data
Files in this Data Supplement:
Jump to section
Related Articles
Cited By...
- Factors Associated with Myocardial Uptake on Oncologic Somatostatin PET Investigations and Differentiation from Myocardial Uptake of Acute Myocarditis
- Visualisation of interstitial lung disease by molecular imaging of integrin {alpha}v{beta}3 and somatostatin receptor 2
- Optimization of a Collagen-Targeted PET Probe for Molecular Imaging of Pulmonary Fibrosis
- Type I collagen-targeted PET probe for pulmonary fibrosis detection and staging in preclinical models
- Matrix Metalloproteinase-Targeted Imaging of Lung Inflammation and Remodeling
- Imaging Pulmonary Inflammation
- PET/CT with 18F-FDG- and 18F-FBEM-Labeled Leukocytes for Metabolic Activity and Leukocyte Recruitment Monitoring in a Mouse Model of Pulmonary Fibrosis
- Preclinical SPECT/CT Imaging of {alpha}v{beta}6 Integrins for Molecular Stratification of Idiopathic Pulmonary Fibrosis