Skip to main content

Main menu

  • Home
  • Content
    • Current
    • Ahead of print
    • Past Issues
    • JNM Supplement
    • SNMMI Annual Meeting Abstracts
  • Subscriptions
    • Subscribers
    • Institutional and Non-member
    • Rates
    • Corporate & Special Sales
    • Journal Claims
  • Authors
    • Submit to JNM
    • Information for Authors
    • Assignment of Copyright
    • AQARA requirements
  • Info
    • Permissions
    • Advertisers
    • Continuing Education
  • About
    • About Us
    • Editorial Board
    • Contact Information
  • More
    • Alerts
    • Feedback
    • Help
    • SNMMI Journals
  • SNMMI
    • JNM
    • JNMT
    • SNMMI Journals
    • SNMMI

User menu

  • Subscribe
  • My alerts
  • Log in
  • My Cart

Search

  • Advanced search
Journal of Nuclear Medicine
  • SNMMI
    • JNM
    • JNMT
    • SNMMI Journals
    • SNMMI
  • Subscribe
  • My alerts
  • Log in
  • My Cart
Journal of Nuclear Medicine

Advanced Search

  • Home
  • Content
    • Current
    • Ahead of print
    • Past Issues
    • JNM Supplement
    • SNMMI Annual Meeting Abstracts
  • Subscriptions
    • Subscribers
    • Institutional and Non-member
    • Rates
    • Corporate & Special Sales
    • Journal Claims
  • Authors
    • Submit to JNM
    • Information for Authors
    • Assignment of Copyright
    • AQARA requirements
  • Info
    • Permissions
    • Advertisers
    • Continuing Education
  • About
    • About Us
    • Editorial Board
    • Contact Information
  • More
    • Alerts
    • Feedback
    • Help
    • SNMMI Journals
  • Follow JNM on Twitter
  • Visit JNM on Facebook
  • Join JNM on LinkedIn
  • Subscribe to our RSS feeds
Meeting ReportOncology - Basic: Basic Science

PBR targeted agents for both tumor nuclear imaging and therapy

Yihui Chen, Munawwar Sajjad, Carrie Batt, Hani Nabi and Ravindra Pandey
Journal of Nuclear Medicine May 2009, 50 (supplement 2) 635;
Yihui Chen
1Roswell Park Cancer Institute, PDT Center, Buffalo, NY
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Munawwar Sajjad
2State University of New York at Buffalo, Nuclear Medicine, Buffalo, NY
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Carrie Batt
1Roswell Park Cancer Institute, PDT Center, Buffalo, NY
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Hani Nabi
2State University of New York at Buffalo, Nuclear Medicine, Buffalo, NY
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Ravindra Pandey
1Roswell Park Cancer Institute, PDT Center, Buffalo, NY
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Info & Metrics
Loading

Abstract

635

Objectives Peripheral benzodiazepine receptor PBR overexpression has been observed in a large variety of human cancers such as ovarian, colon-rectum and breast carcinomas. PK11195, an isoquinoline analog, is one of the PBR ligands of highest PBR binding affinity. Due to the long biological half life of our photosensitizers, there is a need to label it with a longer lived radioisotope. In our present study, our objectives were (i) to synthesize Iodinated-PK11195 and to compare its PBR binding affinity with that of unmodified PK11195, (ii) synthesize and characterize conjugates of one of the chlorophyll-a based photosensitizers developed in our laboratory with I-PK11195 for both imaging (PET) and Photodynamic therapy (PDT), (iii) in vitro and in vivo studies were performed.

Methods I-PK11195 and four of its conjugates with pyropheophorbide-a were synthesized. After investigating their PBR binding affinities, I-PK11195 and one of the conjugates of high PBR binding affinity was converted into the corresponding 124I-derivatives. Serial PET imaging of colon-26 and EMT-6tumor bearing mice was performed using a high-resolution scanner (microPET Focus 120®). Comparative in vitro and in vivo PDT efficacy investigations were also performed.

Results Excellent tumor localization of both 124I-labeled PK11195 and the conjugate was observed. Compared to pyropheophorbide-a, conjugates with PK11195 showed improved its PBR binding affinity, target specificity and PDT efficacy.

Conclusions I-PK11195 can be a good vehicle to deliver the desired photosensitizers to PBR over-expressed tumor regions. Such conjugates could be useful for both tumor imaging (PET) and PDT.

  • © 2009 by Society of Nuclear Medicine
Back to top

In this issue

Journal of Nuclear Medicine
Vol. 50, Issue supplement 2
May 2009
  • Table of Contents
  • Index by author
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for your interest in spreading the word on Journal of Nuclear Medicine.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
PBR targeted agents for both tumor nuclear imaging and therapy
(Your Name) has sent you a message from Journal of Nuclear Medicine
(Your Name) thought you would like to see the Journal of Nuclear Medicine web site.
Citation Tools
PBR targeted agents for both tumor nuclear imaging and therapy
Yihui Chen, Munawwar Sajjad, Carrie Batt, Hani Nabi, Ravindra Pandey
Journal of Nuclear Medicine May 2009, 50 (supplement 2) 635;

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Share
PBR targeted agents for both tumor nuclear imaging and therapy
Yihui Chen, Munawwar Sajjad, Carrie Batt, Hani Nabi, Ravindra Pandey
Journal of Nuclear Medicine May 2009, 50 (supplement 2) 635;
Twitter logo Facebook logo LinkedIn logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One
Bookmark this article

Jump to section

  • Article
  • Info & Metrics

Related Articles

  • No related articles found.
  • Google Scholar

Cited By...

  • No citing articles found.
  • Google Scholar

More in this TOC Section

Oncology - Basic: Basic Science

  • Visualization of human telomerase reverse transcriptase (hTERT) by siRNA probe radiolabeled with technetium-99m in hepatocarcinoma xenografts
  • Human sodium iodide symporter (hNIS)-mediated radioiodine gene therapy modulates phenotype of cancer cell and enhances the killing activity of cytotoxic T cells in a mouse tumor model
  • Imaging fibrosarcoma with Tc-99m labeled polymer pretargeted with bombesin-bispecific antibody complex
Show more Oncology - Basic: Basic Science

Biomarkers and Radiation Effects

  • Analysis of DNA double-strand breaks in gastric cancer cells after treatment with 213Bi-immunoconjugates
  • Validation of 18F-fluorothymidine (FLT) as in vivo molecular probe for measurement of tumor DNA repair synthesis
  • In vivo imaging of long term stem cell trafficking/engraftment is enabled by a human somatostatin receptor type-2 (hSSTR2) mutant that has the desirable features of being muted in altering stem cell signaling and function
Show more Biomarkers and Radiation Effects

Similar Articles

SNMMI

© 2023 Journal of Nuclear Medicine

Powered by HighWire