Comparison of quantitative reliability for FDG-brain by 2D and 3D mode of VUE Point plus and of the conventional

Objectives VUE Point plus (VPP) performs scatter correction concurrently with image reconstruction in the field of view without converting the data acquired by 3D mode into 2D acquisition data. We compared 2D and 3D OSEM of VPP and of the conventional in FDG-Brain.

Methods 1. The 28mm Rod phantoms containing FDG of uniform consistency were placed in spirals at the inner circumference of the 20cm cylindrical phantom. We compared the quantitative reliability in the rod phantoms. 2. 2D and 3D were performed using Hoffman 3D brain phantom. We visually compared difference of resolution and convergence of the image quality.3. 41 trial subjects from 30-68 years old and without brain disease formed the control group. A paired t-test of brain images obtained from 2D and VPP was conducted using SPM99. 4. Defining the above group as the control and PDD as a trial subject, analysis results from SPM99 were compared in 2D and VPP.

Results 1. In average, the difference between 2D and 3D OSEM was -3.0% and the difference between 2D and VPP was 0.5%. 2. Based on the detection of the caudate nucleus, they were detected dividedly in 2D, and it was difficult to detect dividedly in 3D OSEM. They were detected clearly and better than 2D. 3. In a paired t-test of 2D and VPP of the control group, accumulation was significantly increased at the frontal lobe and thalamus, and decreased at the cerebellum in VPP. 4. There is no difference between 2D and VPP in analysis result when comparing PDD and the Control group.

Conclusions Accordingly, VPP is satisfactory for clinical use with sufficient quantitative reliability and high-resolution images.