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Meeting ReportInstrumentation and Data Analysis: Image Generation

Accuracy of absolute activities recovered by three commercial SPECT-CT reconstruction packages using different quantitation techniques

Tyler Hughes, Sergey Shcherbinin and Anna Celler
Journal of Nuclear Medicine May 2009, 50 (supplement 2) 1492;
Tyler Hughes
1University of British Columbia, Vancouver, Canada
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Sergey Shcherbinin
1University of British Columbia, Vancouver, Canada
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Anna Celler
1University of British Columbia, Vancouver, Canada
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Abstract

1492

Objectives Advancements in SPECT-CT technology raise important questions regarding the quality and accuracy of reconstructed images. This multi-center phantom study compares the activities obtained from three modern SPECT-CT systems with their most advanced software packages using three quantitation approaches.

Methods A thorax phantom with a normal 120mL heart and two 33mL bottles filled with Tc-99m solution (clinically relevant concentrations) was scanned (reconstructed) using: Siemens Symbia-T6 (Flash3DTM), GE Infinia Hawkeye (EvolutionTM), and Philips Precedence (AstonishTM). Images were rescaled to absolute activities. Two simple segmentation methods were used to estimate activities by summing the counts within an object’s boundaries determined by: (A) a threshold set to the level of the background and (B) a CT-based exact volume. The third method (C) quantifies activity by recovering spill-out counts and adding them to the counts within the exact volume.

Results Resolution of the reconstructed images differed substantially. Quantitatively, method A overestimated the volumes (up to 410%) and the activities (up to 135%), while the results for method B varied largely between the tested software packages. Activities obtained using method C remained within 10% of the true values with the Astonish reconstruction producing the most accurate results.


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Conclusions Reconstructed images differed and quantitation based on CT did not provide reliable results due to its dependence on image resolution, thus more advanced methodologies (such as method C) must be used.

  • © 2009 by Society of Nuclear Medicine
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Journal of Nuclear Medicine
Vol. 50, Issue supplement 2
May 2009
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Accuracy of absolute activities recovered by three commercial SPECT-CT reconstruction packages using different quantitation techniques
Tyler Hughes, Sergey Shcherbinin, Anna Celler
Journal of Nuclear Medicine May 2009, 50 (supplement 2) 1492;

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Accuracy of absolute activities recovered by three commercial SPECT-CT reconstruction packages using different quantitation techniques
Tyler Hughes, Sergey Shcherbinin, Anna Celler
Journal of Nuclear Medicine May 2009, 50 (supplement 2) 1492;
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