Chemokine receptor 4 is expressed at a higher level in neoplastic tissue than in normal tissue and is a possible predictive marker of metastatic potential. The feasibility of imaging chemokine receptor 4 expression in experimental brain tumors has been shown. SPECT/CT with a ¹²⁵I-labeled monoclonal antibody demonstrated a clear and specific accumulation of radioactivity in the tumors by 24 hours.
See page 1124.