OtherBASIC SCIENCE INVESTIGATIONS

Human Biodistribution and Dosimetry of the D2/3 Agonist 11C-N-Propylnorapomorphine (11C-NPA) Determined from PET

Charles M. Laymon, N. Scott Mason, W. Gordon Frankle, Jonathan P. Carney, Brian J. Lopresti, Maralee Y. Litschge, Chester A. Mathis, James M. Mountz and Rajesh Narendran
Journal of Nuclear Medicine May 2009, 50 (5) 814-817; DOI: https://doi.org/10.2967/jnumed.108.058131

Article Figures & Data

Figures

  • FIGURE 1. 
    FIGURE 1. 

    11C-NPA coronal PET image (hot metal scale) overlaid on attenuation image reconstructed from transmission data (gray scale) for male subject. PET data have been summed over first 4 scans and the image roughly represents activity distribution averaged over first 20 min after injection.

  • FIGURE 2. 
    FIGURE 2. 

    Activity concentration, normalized by injected dose, in various organs as function of time.

Tables

  • TABLE 1

    Research Subject Demographics

    Subject no.SexHeight (cm)Weight (kg)Age (y)
    1F1616922
    2F1686638
    3F1707339
    4M1808220
    5M1756424
    6M1808021
  • TABLE 2

    Average Organ Residence Times

    OrganResidence time (s)
    Liver439.0
    Duodenum252.3
    Urinary bladder106.0
    Kidney97.6
    Lung89.9
    Brain77.2
    Cortical bone46.4
    Gallbladder33.3
    Upper large intestine30.4
    Red marrow25.0
    Lower large intestine17.9
    Heart13.5
  • TABLE 3

    Absorbed Radiation Dose Normalized to Injected Dose (mSv/MBq)

    Dose from…
    Target organβPhotonTotalSD
    Adrenals5.12 × 10−43.29 × 10−33.80 × 10−35.50 × 10−4
    Brain3.65 × 10−31.83 × 10−35.48 × 10−34.89 × 10−4
    Breasts5.12 × 10−49.68 × 10−41.48 × 10−32.57 × 10−4
    Gallbladder wall1.99 × 10−28.26 × 10−32.81 × 10−21.08 × 10−2
    LLI wall4.46 × 10−33.16 × 10−37.62 × 10−31.03 × 10−3
    Small intestine1.99 × 10−24.97 × 10−32.48 × 10−23.98 × 10−3
    Stomach wall5.12 × 10−42.17 × 10−32.68 × 10−33.78 × 10−4
    ULI wall4.76 × 10−35.45 × 10−31.02 × 10−22.14 × 10−3
    Heart wall1.47 × 10−32.20 × 10−33.67 × 10−34.35 × 10−4
    Kidneys2.09 × 10−26.34 × 10−32.72 × 10−25.72 × 10−3
    Liver1.68 × 10−28.27 × 10−32.50 × 10−24.44 × 10−3
    Lungs6.24 × 10−32.30 × 10−38.54 × 10−32.07 × 10−3
    Muscle5.12 × 10−41.43 × 10−31.94 × 10−32.70 × 10−4
    Ovaries5.88 × 10−43.84 × 10−34.43 × 10−32.10 × 10−4
    Pancreas5.12 × 10−43.09 × 10−33.60 × 10−34.87 × 10−4
    Red marrow9.33 × 10−41.84 × 10−32.78 × 10−36.87 × 10−4
    Osteogenic cells2.39 × 10−31.44 × 10−33.83 × 10−39.23 × 10−4
    Skin5.12 × 10−47.75 × 10−41.29 × 10−32.16 × 10−4
    Spleen5.12 × 10−41.93 × 10−32.44 × 10−33.77 × 10−4
    Testes4.35 × 10−49.07 × 10−41.34 × 10−31.45 × 10−4
    Thymus5.12 × 10−41.17 × 10−31.68 × 10−33.03 × 10−4
    Thyroid5.12 × 10−47.66 × 10−41.28 × 10−32.29 × 10−4
    Urinary bladder wall1.82 × 10−26.71 × 10−32.49 × 10−26.28 × 10−3
    Uterus5.88 × 10−43.85 × 10−34.44 × 10−32.06 × 10−4
    Total body1.49 × 10−31.68 × 10−33.17 × 10−34.01 × 10−4

    • LLI wall = lower large intestine wall; ULI = upper large intestine wall.

    • The organ receiving the highest dose was the gallbladder wall. Final column lists standard deviation of total dose across subjects.

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