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Research ArticleCLINICAL INVESTIGATIONS

Quantitative PET Analysis of the Dopamine D2 Receptor Agonist Radioligand 11C-(R)-2-CH3O-N-n-Propylnorapomorphine in the Human Brain

Tatsui Otsuka, Hiroshi Ito, Christer Halldin, Hidehiko Takahashi, Harumasa Takano, Ryosuke Arakawa, Masaki Okumura, Fumitoshi Kodaka, Michie Miyoshi, Mizuho Sekine, Chie Seki, Ryuji Nakao, Kazutoshi Suzuki, Sjoerd Finnema, Yoshio Hirayasu, Tetsuya Suhara and Lars Farde
Journal of Nuclear Medicine May 2009, 50 (5) 703-710; DOI: https://doi.org/10.2967/jnumed.108.058503
Tatsui Otsuka
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Hiroshi Ito
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Christer Halldin
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Hidehiko Takahashi
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Harumasa Takano
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Ryosuke Arakawa
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Masaki Okumura
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Fumitoshi Kodaka
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Michie Miyoshi
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Mizuho Sekine
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Chie Seki
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Ryuji Nakao
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Kazutoshi Suzuki
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Sjoerd Finnema
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Yoshio Hirayasu
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Tetsuya Suhara
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Lars Farde
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Article Information

vol. 50 no. 5 703-710
DOI 
https://doi.org/10.2967/jnumed.108.058503
PubMed 
19372485

Published By 
Society of Nuclear Medicine
Print ISSN 
0161-5505
Online ISSN 
2159-662X
History 
  • Received for publication September 25, 2008
  • Accepted for publication January 21, 2009
  • Published online April 29, 2009.

Article Versions

  • previous version (April 16, 2009 - 12:52).
  • You are viewing the most recent version of this article.
Copyright & Usage 
© 2009 by Society of Nuclear Medicine

Author Information

  1. Tatsui Otsuka 1 , 2 ,
  2. Hiroshi Ito 1 ,
  3. Christer Halldin 3 ,
  4. Hidehiko Takahashi 1 ,
  5. Harumasa Takano 1 ,
  6. Ryosuke Arakawa 1 ,
  7. Masaki Okumura 1 ,
  8. Fumitoshi Kodaka 1 ,
  9. Michie Miyoshi 1 ,
  10. Mizuho Sekine 1 ,
  11. Chie Seki 1 ,
  12. Ryuji Nakao 4 ,
  13. Kazutoshi Suzuki 4 ,
  14. Sjoerd Finnema 3 ,
  15. Yoshio Hirayasu 2 ,
  16. Tetsuya Suhara 1 and
  17. Lars Farde 3
  1. 1Molecular Neuroimaging Group, Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan; 2Department of Psychiatry, Yokohama City University School of Medicine, Yokohama, Japan; 3Psychiatry Section, Department of Clinical Neuroscience, Karolinska Institutet, Karolinska Hospital, Stockholm, Sweden; and 4Molecular Probe Group, Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan
  1. For correspondence or reprints contact: Hiroshi Ito, Molecular Neuroimaging Group, Molecular Imaging Center, National Institute of Radiological Sciences 4-9-1, Anagawa, Inage-ku, Chiba, 263-8555, Japan. E-mail: hito{at}nirs.go.jp
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Journal of Nuclear Medicine: 50 (5)
Journal of Nuclear Medicine
Vol. 50, Issue 5
May 2009
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Quantitative PET Analysis of the Dopamine D2 Receptor Agonist Radioligand 11C-(R)-2-CH3O-N-n-Propylnorapomorphine in the Human Brain
Tatsui Otsuka, Hiroshi Ito, Christer Halldin, Hidehiko Takahashi, Harumasa Takano, Ryosuke Arakawa, Masaki Okumura, Fumitoshi Kodaka, Michie Miyoshi, Mizuho Sekine, Chie Seki, Ryuji Nakao, Kazutoshi Suzuki, Sjoerd Finnema, Yoshio Hirayasu, Tetsuya Suhara, Lars Farde
Journal of Nuclear Medicine May 2009, 50 (5) 703-710; DOI: 10.2967/jnumed.108.058503

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Quantitative PET Analysis of the Dopamine D2 Receptor Agonist Radioligand 11C-(R)-2-CH3O-N-n-Propylnorapomorphine in the Human Brain
Tatsui Otsuka, Hiroshi Ito, Christer Halldin, Hidehiko Takahashi, Harumasa Takano, Ryosuke Arakawa, Masaki Okumura, Fumitoshi Kodaka, Michie Miyoshi, Mizuho Sekine, Chie Seki, Ryuji Nakao, Kazutoshi Suzuki, Sjoerd Finnema, Yoshio Hirayasu, Tetsuya Suhara, Lars Farde
Journal of Nuclear Medicine May 2009, 50 (5) 703-710; DOI: 10.2967/jnumed.108.058503
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  • In Vitro Pharmacological Characterization and In Vivo Validation of LSN3172176 a Novel M1 Selective Muscarinic Receptor Agonist Tracer Molecule for Positron Emission Tomography
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